نتایج جستجو برای: interleukin 1 gene cluster

تعداد نتایج: 3754786  

2012
Sandra Olsson Marketa Sjögren Olle Melander

Background and Purpose—Evidence is emerging that inflammation plays a key role in the pathophysiology of ischemic stroke (IS). The aim of this study was to investigate whether genetic variation in the interleukin-1␣, interleukin-1␤, and interleukin-1 receptor antagonist genes (IL1A, IL1B, and IL1RN) is associated with IS and/or any etiologic subtype of IS. Methods—Twelve tagSNPs were analyzed i...

Journal: :Haematologica 2003
Branislav Vohnout Augusto Di Castelnuovo Roberto Trotta Andria D'Orazi Gaetano Panniteri Anna Montali Maria Benedetta Donati Marcello Arca Licia Iacoviello

BACKGROUND AND OBJECTIVES The pro-inflammatory cytokine interleukin (IL)-1 has been suggested to play a role in atherosclerosis. Several genetic polymorphisms have been described in the genes of the IL-1 cluster and associations with coronary artery disease (CAD) have been reported, although with contrasting results. DESIGN AND METHODS The associations of a variable number tandem repeat (86 b...

Journal: :Clinical chemistry 2006
Georg Endler Rodrig Marculescu Philipp Starkl Alexander Binder Gotho Geishofer Martin Müller Bettina Zöhrer Bernhard Resch Werner Zenz Christine Mannhalter

BACKGROUND An association has been described between mortality in children with meningococcal disease and functional polymorphisms in the interleukin-1 (IL1) cluster. We undertook a multicenter study to evaluate associations of these polymorphisms in a Central European population. PATIENTS AND METHODS The study involved 95 Middle European pediatric hospitals. We collected blood samples from, ...

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