background: interferons (ifns) are common therapeutics for several diseases such as viral hepatitis, multiple sclerosis and malignancy. a variety of autoimmune related side effects have been observed during ifn therapy. rare cases of myopathy, polymyositis or dermatomyositis have been reported during therapy with high doses of ifn^5. case presentation: in this report, we describe a case with se...

BACKGROUND & AIMS CD95 (Apo-1/Fas) ligand suppresses inflammatory responses in immune-privileged organs. In this study, modulation of the hepatic CD95 receptor/ligand system by interferon gamma and cyclosporin A was investigated. METHODS CD95 receptor and ligand expression were measured at the messenger RNA level by using quantitative reverse-transcription polymerase chain reaction and immuno...

Interferon-alpha (IFN-alpha)-mediated intracellular signaling is initiated by ligand-induced receptor dimerization, tyrosine phosphorylation of the Tyk2 and Jak1 tyrosine kinases, and subsequent phosphorylation of the Stat1 and Stat2 proteins. The IFN-alpha receptor consists of at least two distinct subunits. One subunit, IFNAR1, has low affinity binding for interferon yet is required for signa...

2. Jouanguy E, Altare F, Lamhamedi S, Revy P, Emilie J-F, Levin M, et al. Interferonγ–receptor deficiency in an infant with fatal bacille Calmette-Guérin infection. N Engl J Med. 1996;26:1956–60. 3. Casanova JL, Blanche S, Emile JF, Jouanguy E, Lamhamedi S, Altare S, et al. Idiopathic disseminated bacillus CalmetteGuérin infection: a French national retrospective study. Pediatrics. 1996;98:774–...

In the past ten years the oestrogen antagonist tamoxifen has played an increasingly important role in the management of primary and metastatic breast cancer. Although the mechanism of action of tamoxifen is imprecisely understood, there is considerable evidence that it acts primarily by blocking oestrogen action at its receptor. Interferon, in contrast to tamoxifen, has been disappointing as a ...

Abstract While some individuals infected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) present mild-to-severe disease, many SARS-CoV-2-infected are asymptomatic. We sought to identify the distinction of immune response between asymptomatic and moderate patients. performed single-cell transcriptome T-cell/B-cell receptor (TCR/BCR) sequencing in 37 longitudinal collected periphe...

Type I interferon inducers may potentially be engineered to function as antiviral and anticancer agents, or alternatively, vaccine adjuvants, all of which may have clinical applications. We recently described a simple strategy to convert a Toll-like receptor 9 (TLR9) agonist devoid of interferon α (IFNα) stimulating activity into a robust Type I interferon inducer with potent vaccine adjuvant a...

The receptor for human interferon-y (IFN-y) was purified from foreskin fibroblasts. Triton X-100 extracts obtained from either intact cells or membrane preparations were passed through an immobilized interferon-? column. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) of eluted fractions revealed a major band of M, = 95,000 and minor bands of M. = 80,000 and 60,000. Further...