chronic hepatitis c might lead to several immunological dysfunctions. studies have shown a positive association between hepatitis c virus (hcv) infection and psoriasis. these results suggest that the infection may be one of the triggering factors for the development or exacerbation of psoriasis. here, we present a case of chronic hcv infection with psoriasis who developed exacerbation of skin l...

Background: Statins, widely used cholesterol-lowering agents, have also been demonstrated to have anti-inflammatory and immunomdulatory effects. Objective: To evaluate the effects of atorvastatin in combination with Interferon-β in the treatment of multiple sclerosis (MS) in a randomized controlled clinical trial. Methods: Multiple sclerosis patients were randomized independently, in a double b...

Human Interferon β (INF-β) is a member of cytokines family which different studies have shown its immunomodulatory and antiviral activities. In this study an expression vector was designed and constructed for expression of human INF-β-1b either in shake flasks and bench top bioreactor. The designed vector was constructed based upon pET-25b(+) with T7 promoter. Recombinant human beta interferon ...

up to 30% of iranian adult multi-transfused thalassemic patients are infected with hepatitis c virus (hcv) which can intensify the progression of liver disease caused by iron overload in this group of patients. our aim was to assess the biochemical and virological response of interferon alfa (inf-α) and its safety in thalassemic patients with chronic hcv infection. this trial was a single cente...

this preliminary study was designed to evaluate the effects of heberon alfa for the treatment of chronic hepatitis b infected subjects in iran. a single center, open label, single treatment prospective study of interferon alfa (heberon alfa), 5 million units every other day for a period of 4 months, was performed between 1996 to 1998. a total number of 30 patients with histologically documented...

Background and Aims: Interferon alpha is an effective cytokine in viral infections, where it has various roles in immune function. The use of this antiviral agent in the treatment of viral infections and even cancers is common, although, the beneficial effects of this antiviral agent in high doses can be associated with side effects that limit its use. In this project, we tried to investigate t...

BACKGROUND : Interferon-gamma (INF-γ) is an important cytokine in the immune response against Mycobacterium tuberculosis. activates macrophage to kill intracellular mycobacterium. AIM: The aim of this study determine difference plasma INF-γ level pulmonary tuberculosis (PTB) patients compared a healthy control and factors associated with interferon-gamma level. METHODS: This case–control study....