introduction: in the present work, spontaneous postsynaptic currents were assessed to investigate the postnatal development of excitatory postsynaptic currents in locus coeruleus neurons. methods: in this study, ampa and nmda receptor-mediated spontaneous synaptic currents in the neurons of locus coeruleus were assessed using whole cell voltage-clamp recording during the first three weeks. resu...

The idea of Communitarianism with epistemic teachings, such as politics as virtue, the priority of good faith, respect for the cultural diversity of societies, is one of the most prominent intellectual currents of the present age. The hypothesis of this research is that based on the comparative analytical attitude of key societal teachings and the epistemic principles of Islam, one can find com...

the goal of this study was to determine the effects of the l-type calcium channel blockers verapamil and diltiazem on the currents of voltage-gated potassium channel (fkv1.4δn), an n-terminal-deleted mutant of the ferret kv1.4 potassium channel. measurements were made using a two electrode voltage clamp technique with channels expressed stably in xenopus oocytes. the fkv1.4δn currents displayed...

In science we like to emphasize the novelty and originality of our ideas. This is harmless enough, provided it does not blind us to the fact that concepts rarely arise out of nowhere. There is always a historical context, in which isolated precursors of the idea have already appeared. What we call "discovery" sometimes looks, in retrospect, more like emergence into the air from subterranean int...

background: ketamine is a commonly used intravenous anesthetic which produces dissociation anesthesia, analgesia, and amnesia. the mechanism of ketamine-induced synaptic inhibition in high-level cortical areas is still unknown. we aimed to elucidate the effects of different concentrations of ketamine on the glutamatergic synaptic transmission of the neurons in the primary somatosensory cortex b...

Maturana advanced the rst systematic explanation of cognition based solely on biological principles since Aristotle. This was a risky strategy to adopt, given the intellectual currents of his time. Had it been more inuential, the autopoietic theory of cognition might well have brought us much sooner to the trends currently at the forefront of the cognitive sciences, including dynamical system...

Heterozygous mutations or deletions in the human Euchromatin histone methyltransferase 1 (EHMT1) gene cause Kleefstra syndrome, a neurodevelopmental disorder that is characterized by autistic-like features and severe intellectual disability (ID). Neurodevelopmental disorders including ID and autism may be related to deficits in activity-dependent wiring of brain circuits during development. Alt...