PURPOSE The canonical wingless and Int1 (Wnt) signaling pathway plays key roles in multiple biologic events. The pathway co-receptor, low density lipoprotein receptor-related protein 5 (LRP5), is involved in the pathogenesis of retinal diseases and has been implicated in glaucoma. We studied whether a disease-associated polymorphism LRP5.Q89R, which is located in the second blade of the first β...

Different modulatory inputs commonly elicit distinct rhythmic motor patterns from a central pattern generator (CPG), but they can instead elicit the same pattern. We are determining the rhythm-generating mechanisms in this latter situation, using the gastric mill (chewing) CPG in the crab (Cancer borealis) stomatogastric ganglion, where stimulating the projection neuron MCN1 (modulatory commiss...

A novel p-terphenyl diphosphine ligand was synthesized with a noninnocent hydroquinone moiety as the central arene (1-H). Pseudo-tetrahedral 4-coordinate Ni(0) and Pd(0)-quinone (2 and 3, respectively) complexes proved accessible by metalating 1-H with the corresponding M(OAc)2 precursors. O2 does not react with the Pd(0)-quinone species (3) and protonation occurs at the quinone moiety indicati...

Agriculture, and the related food systems, represents one of sectors that use most available water resources is responsible for a large part greenhouse gases increase in Earth’s atmosphere. The aim present research was to estimate three dimensions sustainability—identified by 2030 Agenda—of olive oil supply chain typical production area within Campania Region (South Italy), through analysis sev...

PURPOSE To evaluate the possibility of genetic involvement in retinopathy of prematurity (ROP). Although ROP is most often associated with low birthweight and low gestational age, these factors do not necessarily predict the severity of ROP. The possible involvement of other factors, including genetic variants, has been considered. Familial exudative vitreoretinopathy (FEVR) is a hereditary vit...

BACKGROUND Extensive use of cotrimoxazole has been associated with increasing level of Escherichia coli resistance. OBJECTIVES In the current study, we focused on assessing the prevalence of E. coli resistance to cotrimoxazole and frequency of its associated genes. MATERIALS AND METHODS One-hundred and forty-four E. coli isolates were identified during March 2007 to April 2012 at Ilam hospi...

We established a differentiation method for homogeneous α7 integrin-positive human skeletal muscle stem cell (α7⁺hSMSC)-derived osteoblast-like (α7⁺hSMSC-OB) cells, and found that interleukin (IL)-1β induces matrix metalloproteinase (MMP)-13-regulated proliferation of these cells. These data suggest that MMP-13 plays a potentially unique physiological role in the regeneration of osteoblast-like...