meniere’s disease is the disorder of inner ear characterized by vertigo, tinnitus and sensorineural hearing loss. the vestibular evoked myogenic potential (vemp) test could be useful in the analysis of saccular function, and diagnosis of meniere’s disease. in this study, we’ve analyzed the saccular function, using vemp test in different groups of meniere’s disease. patients were categorized as ...

Bone conduction describes the mechanisms that produce a hearing sensation when the skull bones are subjected to vibration. Multiple components and pathways have been suggested to contribute to total bone-conducted sound. They include outer-ear cartilaginous wall compression, middle-ear inertia, fluid inertia, cochlear capsule compression and soft-tissue conduction. Due to the complexity of the ...

Transtympanic gentamicin administration has become a popular modality in the treatment of Ménière's disease. This modality and other inner-ear medical therapy are gaining increased clinical and scientific attention. We previously described the kinetics and effects of gentamicin uptake into the inner ear after delivery of the medicine into the middle ear using a variety of different techniques a...

The inner ear, composed of the cochlea and the vestibule, is a specialized sensory organ for hearing and balance. Although the inner ear has been known as an immune-privileged organ, there is emerging evidence indicating an active immune reaction of the inner ear. Inner ear inflammation can be induced by the entry of proinflammatory molecules derived from middle ear infection. Because middle ea...

HYPOTHESIS That a theoretical basis for quantifying drug distribution in the inner ear with local applications can be established. BACKGROUND As methods of local drug delivery to the inner ear gain wider clinical acceptance it becomes important to establish how drugs are distributed in the ear as a function of time and for different delivery methods. METHODS The time course of gentamicin co...

The inner ear is a structurally complex vertebrate organ built to encode sound, motion, and orientation in space. Given its complexity, it is not surprising that inner ear dysfunction is a relatively common consequence of human genetic mutation. Studies in model organisms suggest that many genes currently known to be associated with human hearing impairment are active during embryogenesis. Henc...