The treatment of hypercholesterolemia entered in a new phase of development with the introduction of proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors in the market. The Food and Drug Administration and European Medicines Agency recently approved the alirocumab and evolocumab, subcutaneously injectable monoclonal antibody every 2 or 4 weeks against PCSK9, for the treatment of hyp...

Through improved adherence, once-monthly injectable extended-release naltrexone (XR-NTX) may provide an advantage over other oral agents approved for alcohol and opioid dependence treatment. The objective of this study was to evaluate cost and utilization outcomes between XR-NTX and other pharmacotherapies for treatment of alcohol and opioid dependence. Published studies were identified through...

Alison Beaney is regional quality assurance specialist based at The Royal Victoria Infirmary, Newcastle upon Tyne, Anne Black is quality assurance pharmacist and Clare Dobson is a basic grade pharmacist at Freeman Hospital, Newcastle upon Tyne, and Steve Williamson is lead pharmacist for cancer services at Northumbria Healthcare Trust. Mark Robinson is a pre registration trainee at Sunderland R...

Results Establishment of clubs and registers increased known prevalence across Indonesia: a 4.5 fold increase in CAH, from 65 patients (2008) to 293 (2014); 2 fold increase in OI, from 35 patients (2013) to 70 (2014); 5 fold increase in Diabetes, from 156 patients (2009) to 960 (2014). Access to medicines improved: donations of hydrocortisone (oral and injectable) and fludrocortisone co-ordinat...

Hydrogels have been used for biomedical applications in recent decades. They are a perfect candidate for regenerative medicine as they resemble the extracellular matrix of native tissues. In addition, their highly hydrated structure makes them a suitable choice for drug and other therapeutics delivery. Injectable hydrogels have increasingly gained attention due to their capability for homogeneo...

atropine (at) and oximes, alone or in combination, have been proven greatly valuable therapeutics in the treatment of organophosphates intoxications. an injectable mixture of at and obidoxime (ob) was formulated for administration by automatic self-injector. the aqueous single dose solution contained 275 mg obidoxime chloride and 2.5 mg atropine sulfate per 1 ml (220 mg and 2 mg per 0.8 effecti...

objective: to compare side effects between users of two kinds of injectable contraceptives (depo-medroxy progesterone acetate and cyclofem). materials and methods: this cross-sectional descriptive study included 250 women, aged 18-40 years, using depo-medroxy progesterone acetate (dmpa) or cyclofem. the volunteers were examined six months after using contraceptive, and they were asked about fol...

OBJECTIVE Determining prescription patterns for outpatient medication authorised for patients affiliated to an EPS and assisted by medium- and high-level complexity IPS. METHODS This was a cross-sectional study where medication prescription was evaluated in 331 second- and third-level complexity hospitals from 27 Colombian departments during 2006. RESULTS 38 863 prescriptions for 3 663 pati...

Antimicrobial resistance is a major global concern. Tuberculosis (TB) strains resistant to rifampicin and other TB medicines challenge patient survival and public health. The World Health Organization (WHO) has published treatment guidelines for drug-resistant TB since 1997 and last updated them in 2016 based on reviews of aggregated and individual patient data from published and unpublished st...