Long-acting injectable antipsychotics constitute a valuable alternative for the treatment of psychotic disorders, mainly schizophrenia. They assure a more stable drug level, improve treatment compliance, and increase the chances for favorable and long-lasting improvement. Additionally, the long-acting second-generation antipsychotics combine the values of long-acting injectable drugs with the v...

The second paragraph beginning on page 2 reads: In this review, we define injectable pharmaceutical coformulations as preparations, and which also maintain their distinct pharmacological properties. These are distinct from the pre-mixed insulins that have been available over the last 50 years (Table 1). It should instead read: In this review, we define injectable pharmaceutical coformulations a...

In the field of tissue engineering, there is a need for advancement beyond conventional scaffolds and preformed hydrogels. Injectable hydrogels have gained wider admiration among researchers as they can be used in minimally invasive surgical procedures. Injectable gels completely fill the defect area and have good permeability and hence are promising biomaterials. The technique can be effective...

Injectable hydrophobic drugs are typically dissolved in surfactants and non-aqueous solvents which can induce negative side-effects. Alternatives like 'top-down' fine milling of excipient-free injectable drug suspensions are not yet clinically viable and 'bottom-up' self-assembled delivery systems usually substitute one solubilizing excipient for another, bringing new issues to consider. Here, ...

WHO standard indicators of rational drug use, this study analysed 550 prescriptions from 20 health facilities at different levels throughout Hadramout governorate, Yemen. A mean of 2.8 (SD 0.2) drugs were prescribed per prescription, with a low rate of prescribing drugs by generic name (39.2%). The proportion of prescriptions for antibiotics was 66.2%, for injectable drugs 46.0% and for vitamin...

Multi-drug resistant tuberculosis (MDRTB) is defined as a strain of Mycobacterium tuberculosis with resistance to at least isoniazid (H) and rifampicin (R), the two key drugs in TB treatment. Very recently, extensively drug-resistant tuberculosis (XDRTB) has gained notoriety and is defined as MDRTB with additional resistance to any fluoroquinolone, and to at least one of three injectable second...

Rational prescribing increases the quality of health care and patient outcomes. In this study, the quality of drug prescription in specialist physicians in Isfahan province of Iran was assessed for evaluating the rational use of drugs and improving the therapeutic outcomes. This retrospective survey was conducted on a total of 7999530 prescriptions from all general and specialist physicians. Th...

Poor drugability problems are commonly seen in a class of chemical entities with poor solubility in water and oil, and moreover, physicochemical instability of these compounds poses extra challenges in design of dosage forms. Such problems contribute a significant high failure rate in new drug development. A hybrid nanoparicle-in-oil-in-water (N/O/W) submicron emulsion was proposed for improved...

BACKGROUND Harmful medication errors, or preventable adverse drug events (ADEs), are a prominent quality and cost issue in healthcare. Injectable medications are important therapeutic agents, but they are associated with a greater potential for serious harm than oral medications. The national burden of preventable ADEs associated with inpatient injectable medications and the associated medical ...