نتایج جستجو برای: inhibitory antibodies
تعداد نتایج: 284372 فیلتر نتایج به سال:
Previously described monoclonal antibodies to porcine Willebrand factor were used to study various functional assays of Willebrand factor. These antibodies comprise at least five separate specificities as determined by differential reactivity in three distinct binding assays. The antibodies were tested for their effect on the in vivo bleeding time, in vitro bleeding time, and ristocetin cofacto...
PEGylation of antibodies is known to increase their half-life in systemic circulation, but nothing is known regarding whether PEGylation can improve the inhibitory potency of antibodies against target receptors. In this paper, we have examined this question using antibodies directed to Sialoadhesin (Sn), a macrophage-restricted adhesion molecule that mediates sialic acid dependent binding to di...
BACKGROUND Grass pollen immunotherapy for allergic rhinitis is a disease-modifying treatment that results in long-term clinical tolerance lasting years after treatment discontinuation. Active treatment is associated with generation of inhibitory grass pollen-specific IgG antibodies capable of blocking allergen-IgE interactions. OBJECTIVES We sought to investigate the involvement of IgG-associ...
Antibodies prepared against an insoluble-soluble glucan-synthesizing fraction significantly inhibited in vitro adherence of Streptococcus mutans, whereas antibodies directed against a soluble glucan-synthesizing fraction were much less inhibitory.
The glutamate-rich protein (GLURP) is an exoantigen expressed in all stages of the Plasmodium falciparum life cycle in humans. Anti-GLURP antibodies can inhibit parasite growth in the presence of monocytes via antibody-dependent cellular inhibition (ADCI), and a major parasite-inhibitory region has been found in the N-terminal R0 region of the protein. Herein, we describe the antiplasmodial act...
Specific CD8+ T cells are crucial for the control of viruses. However, during many chronic viral infections these become dysfunctional. Immune checkpoint receptors, like PD-1 expressed on cells, contribute to this functional suppression infection. acute phase infection virus-specific express high levels but fully competent in killing virus-infected and there is increasing evidence that biologic...
We have examined the roles of the p85/ p110 a and hVPS34 phosphatidylinositol (PI) 3 9 -kinases in cellular signaling using inhibitory isoform-specific antibodies. We raised anti-hVPS34 and anti-p110 a antibodies that specifically inhibit recombinant hVPS34 and p110 a , respectively, in vitro. We used the antibodies to study cellular processes that are sensitive to lowdose wortmannin. The antib...
We have examined the roles of the p85/ p110alpha and hVPS34 phosphatidylinositol (PI) 3'-kinases in cellular signaling using inhibitory isoform-specific antibodies. We raised anti-hVPS34 and anti-p110alpha antibodies that specifically inhibit recombinant hVPS34 and p110alpha, respectively, in vitro. We used the antibodies to study cellular processes that are sensitive to low-dose wortmannin. Th...
RNAi effectors (e.g. siRNA, shRNA and miRNA) can trigger the silencing of specific genes causing alteration genomic functions becoming a new therapeutic area for treatment infectious diseases, neurodegenerative disorders cancer. In cancer treatment, showed potential immunomodulatory actions by down-regulating immuno-suppressive proteins, such as PD-1 CTLA-4, which restrict immune cell function ...
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