نتایج جستجو برای: inherited inferiority
تعداد نتایج: 34895 فیلتر نتایج به سال:
BACKGROUND There is concern that non-inferiority trials might be deliberately designed to conceal that a new treatment is less effective than a standard treatment. In order to test this hypothesis we performed a meta-analysis of non-inferiority trials to assess the average effect of experimental treatments compared with standard treatments. METHODS One hundred and seventy non-inferiority trea...
PURPOSE Epidermal growth factor receptor (EGFR) inhibitors are approved for treating metastatic colorectal cancer (CRC); KRAS mutation testing is recommended prior to treatment. We conducted a non-inferiority analysis to examine whether KRAS testing has impacted survival in CRC patients. PATIENTS AND METHODS We included 1186 metastatic CRC cases from seven health plans. A cutpoint of July, 20...
Non-inferiority (NI) trials attempt to demonstrate that the loss in efficacy by a new treatment compared to a standard treatment is limited to a certain pre-specified margin, usually compensated by some form of benefit in the form of safety, ease in administration, tolerability, costs, etc. The lack of mention of the benefit of the new treatment and its importance have been pointed out recently...
Background: Marital infidelity damages the intimate relations of couples and by exposing it, the tensions of the spouses increase and the marital adjustment of the spouses is damaged. In this regard, the present study was conducted to determine the effectiveness of group narrative therapy on feelings of inferiority and attachment styles of married women with experience of extramarital relations...
Unfortunately, the original version of this article [1] contained an error. The correct paragraph can be found below: The calculation of number of patients was not correct. It was wrote the non-inferiority margin as 0.1 mm. But it was 0.19 mm in an original document. Non-inferiority margin in previous coronary intervention studies has been set between 0.1 ~ 0.2 mm. The 0.19 mm is not irrelevant...
BACKGROUND Subjects with breast cancer enrolled in trials may experience multiple events such as local recurrence, distant recurrence or death. These events are not independent; the occurrence of one may increase the risk of another, or prevent another from occurring. The most commonly used Cox proportional hazards (Cox-PH) model ignores the relationships between events, resulting in a potentia...
A South Wales gypsy kindred of Romany origin had a high incidence of phenylketonuria along with other recessively inherited disorders. There was a high degree of consanguinity (F = 0-017) with an excess of non-specific mental subnormality among known consanguineous matings. Phenylketonuria and a number of other recessively inherited disorders have been recorded from other Romany gypsy populatio...
cellular and molecular pathways link thrombosis and innate immune system during sepsis. extrinsic pathway activation of protease thrombin through fviia and tissue factor (tf) in sepsis help activate its endothelial cell (ec) membrane protease activated receptor 1 (par-1). thrombin adjusts the ec cycle through activation of g proteins (g12/13), and later through rho gefs (guanine nucleotide exch...
In drug development, non-inferiority tests are often employed to determine the difference between two independent binomial proportions. Many test statistics for non-inferiority are based on the frequentist framework. In this paper, we propose a method for the determination of sample sizes using the index ( ) , , 2 1 0 2 1 X X P ∆ − π > π = τ where 1 X and 2 X denote binomial random variables fo...
BACKGROUND Non-inferiority and equivalence trials require tailored methodology and therefore adequate conduct and reporting is an ambitious task. The aim of our review was to assess whether the criteria recommended by the CONSORT extension were followed. METHODS We searched the Medline database and the Cochrane Central Register for reports of randomised non-inferiority and equivalence trials ...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید