Inhalation anesthesia with isoflurane is a well-established and safe method used in small laboratory animals. In most cases oxygen is used as a carrier gas for isoflurane, but room air or mixtures of oxygen with air or nitrous oxide are also being used. Anesthesia is therefore administered using different fractions of inspired oxygen (FiO2), and this may have consequences for the outcome of exp...

Inhalation anesthesia is the main method used for maintenance of anesthesia in dogs. One of the most important drawbacks of this technique, however, is that it pollutes the environment. Total intravenous anesthesia, or TIVA, can provide a valuable alternative to this method, an alternative whereby several different drugs or drug combinations and different means of administration can be used. De...

BACKGROUND The underlying mechanism for the increased alveolar-arterial oxygen tension difference resulting from almost all forms of general anesthesia is unknown. We hypothesized that inhalation anesthesia influences the intrapulmonary distribution of ventilation (V) and perfusion (Q), leading to less advantageous V/Q matching. METHODS Ten healthy volunteers were studied in supine position o...

The non-invasive Xe inhalation method was modified to measure regional cerebral blood flow (rCBF) of both hemispheres and brain stem-cerebellar (BSC) regions in baboons to serve as a model for clarifying and validating human studies. Measurements were made in the alert, unanesthetized state at rest and during activation with spontaneous respiration in a primate chair or during sedation or anest...

BACKGROUND Many studies have evaluated risk factors associated with complications after free flap surgery, but these studies did not evaluate the impact of anesthesia management. The goal of the current study was to evaluate the differences between patients who received inhalation and total intravenous anesthesia (TIVA) in free flap surgery. METHODS One hundred and fifty-six patients who unde...

Hypoxic Pulmonary Vasoconstriction (HPV) was first reported by Bindsley et al. in adult patients and was managed using double lumen catheters to ventilate one lung with 100% oxygen and the other with 95% N2 and 5% oxygen during intravenous barbiturate and fentanyl anesthesia. However, ‘‘HPV inhibition’’ has predominantly been attributed to the use of inhalation agents and is considered as a cau...

hypoxemia under certain conditions. However, the relationship between pulmonary anesthetic administration and HPV remains controversial. In conclusion, global effects of inhalation induction with sevoflurane at high concentrations may cause oxygen desaturation in lungs that are normally ventilated with 100% oxygen, potentially resulting in global inhibition of HPV. However, these conditions may...

hypoxemia under certain conditions. However, the relationship between pulmonary anesthetic administration and HPV remains controversial. In conclusion, global effects of inhalation induction with sevoflurane at high concentrations may cause oxygen desaturation in lungs that are normally ventilated with 100% oxygen, potentially resulting in global inhibition of HPV. However, these conditions may...