Sir, Inhalants are commonly abused drugs in adolescent population though often unrecognized. On long‐term use they can result in serious sequels like optic atrophy and psychosis, resembling schizophrenia, and thus need awareness among physicians and psychiatrists. While there have been case reports on inhalant abuse in India,[1] there has been no report describing psychosis following toluene us...

BACKGROUND Abuse of harmful legal products that can be inhaled or ingested is a serious and growing problem in many rural Alaskan communities, and particularly so among preteens. METHODS This study analyses data collected during baseline measurements of a 5-year NIH/NIDA-funded study entitled A Community Trial to Prevent Youth's Abuse of Harmful Legal Products in Alaska. Youth in 8 communitie...

Inhalants are distinguished as a class primarily based upon a shared route of administration. Grouping inhalants according to their abuse-related in vivo pharmacological effects using the drug discrimination procedure has the potential to provide a more relevant classification scheme to the research and treatment community. Mice were trained to differentiate the introceptive effects of the tric...

The use of oral fluid as a biological matrix to monitor the use of drugs of abuse is a global trend because it presents several advantages and good correlation to the blood level. Thus, the present work aimed to develop and validate an analytical method for quantification and detection of solvents used as inhalants of abuse in oral fluid (OF), using Quantisal™ as collector device by headspace a...

OBJECTIVE To evaluate the effects of Project ALERT on adolescents' lifetime and 30-day use of cigarettes, alcohol, marijuana, and inhalants. DESIGN Cluster randomized trial. SETTING Schools from 11 states were enrolled in 2 successive cohorts from 2004 to 2008. PARTICIPANTS All public schools in the United States that included grades 6 through 8 and enrolled at least 100 students in sixth...

Recent studies suggest that alcohols, volatile anesthetics, and inhaled drugs of abuse, which enhance gamma-aminobutyric acid, type A, and glycine receptor-activated ion channel function, may share common or overlapping molecular sites of action on these receptors. To investigate this possibility, these compounds were applied singly and in combination to wild-type glycine alpha(1) receptors exp...