Activation of Shh signaling is known to be observed following injury of the peripheral nerves such as the sciatic nerve. However, the precise role of Shh signaling during peripheral nerve regeneration is not fully understood. The inferior alveolar nerve (IAN) is most commonly injured during oral surgery. Unlike the sciatic nerve, the IAN is isolated from other craniofacial tissues, as it reside...

The trigeminal nerve is the largest peripheral sensory nerve in the human body and is represented by over 40% of the sensory cortex. The nerve supplies the face, eyes, mouth and scalp with general sensation in three divisions (ophthalmic, maxillary and mandibular) and supplies the mastication muscle. In addition the most commonly injured trigeminal nerve branches, the inferior alveolar and ling...

The inferior alveolar nerve (IAN) and lingual (LN) are susceptible to iatrogenic surgical damage. Systematically review recent clinical evidence regarding IAN/LN repair methods and to develop updated guidelines for managing injury. Recent publications on IAN/LN microsurgical repair from Medline, Embase and Cochrane Library databases were screened by title/abstract. Main texts were appraised for...

A case of orofacial pain and inferior alveolar nerve (IAN) paraesthesia after extrusion of endodontic sealer within the mandibular canal treated with prednisone and pregabalin is described. A 36-year-old woman underwent root canal treatment of the mandibular second right premolar tooth. Post-operative panoramic radiograph revealed the presence of radiopaque canal sealer in the mandibular canal....

This paper proposes a feature selection based classification method that can be applied to better accuracy in the Digital Radiographs (DR) for the identification of Inferior Alveolar Nerve Injury (IANI). Different conventional features based on the shape and EZW (Embedded Zero tree Wavelet) based texture features are extracted using different feature extraction techniques. Then, aggregate votin...

The purpose of this study was to analyze the incidence and risk factors possible inferior alveolar nerve (IAN) injury after extraction mandibular third molars. A total 6182 patients were examined for 10,310 molar teeth. Panoramic radiography patients’ medical records used age, gender, impaction pattern molar. Cone beam computed tomography (CBCT) investigate detailed pathway evaluated presence s...

One of the most common oral surgical procedures is the extraction of the lower third molar (LTM). Postoperative complications such as paresthesia due to inferior alveolar nerve (IAN) injury are commonly observed in cases of horizontal and vertical impaction. The present report discusses a case of a vertically impacted LTM associated with a dentigerous cyst. An intimate contact between the LTM r...

paresthesia is a burning or prickling sensation or partial numbness, resulting from neural injury. the symptoms can vary from mild neurosensory dysfunction to total loss of sensation in the innervated area. only a few cases have described apical periodontitis to be the etiological factor of impaired sensation in the area innervated by the inferior alveolar and mental nerves. the aim of the pres...

PURPOSE Close proximity of the inferior alveolar nerve (IAN) to the third molar roots can result in nerve injuries during extraction of third molars. Consequently, it is necessary to determine the relationship of the nerve and roots to avoid damage to the IAN. Computed tomography scans are widely used to determine the correct relationship between the IAN and lower third molars. PATIENTS AND M...