tumor necrosis factor- α (tnf-α) plays an important role in diverse cellular events such as septic shock, induction of other cytokines, cell proliferation and apoptosis. tumor necrosis factor (tnf)-related apoptosis-inducing ligand (trail) is currently attracting great interest as a potential anticancer drug. trail could selectively induce apoptosis in tumor cells in vitro and in vivo by a deat...

introduction: multiple sclerosis (ms) is a chronic inflammatory demyelinating disorder of the central nervous system with various degrees of axonal damage. the tnf-related apoptosis inducing ligand receptor (trail-r) might be playing an important role in the pathogenesis of ms. the objective of our study was to evaluate the association of two common polymorphisms is located in the trail-r1 and ...

LGK974 is a potent Wingless-related integration site inhibitor at Phase II of clinical trial. However, little known about its role and the underlying mechanisms in human hepatocellular carcinoma. 3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide colony formation assays were used to determine cytotoxicity on liver cancer cell lines. Flow cytometry assay was performed examine apoptosis...