Placental oxidative stress is a feature of both human labor and the pregnancy syndrome preeclampsia. Heat shock proteins (HSPs) can be induced in cells as a protective mechanism to cope with cellular stress. We hypothesized that HSP 70 would increase during labor and preeclampsia and that expression would vary in different placental zones. Samples were obtained from 12 sites within each placent...

We tested the hypothesis that oxytocin-induced labor augmented IL-1beta-induced/-stimulated lung fluid absorption in preterm guinea pig fetuses. IL-1beta was administered subcutaneously daily to timed-pregnant guinea pigs for 3 days with and without simultaneous cortisol synthesis inhibition by metyrapone. At day 3, oxytocin was administered, and fetuses were delivered by abdominal hysterotomy ...

BACKGROUND The diagnosis of labor onset has been described as one of the most important judgments in maternity care. There is compelling evidence that the duration of both latent and active phase labor are clinically important and require consistent approaches to measurement. In order to measure the duration of labor phases systematically, we need standard definitions of their onset. We reviewe...

the nonlinear budget set in the labor supply application, Figure A1 depicts a nonlinear budget set induced by a simple progressive tax. The after-tax wage, w, that a worker faces varies with the tax rate, t.2 The labor supply application examines the effect of the after-tax wage (the slope) on hours (the horizontal axis) controlling for income (the vertical axis). Similarly, I examine the effec...

Recent evidence suggests that leukocytes infiltrate uterine tissues at or around the time of parturition, implicating inflammation as a key mechanism of human labor. MCP-1 (also known as C-C chemokine motif ligand 2, CCL-2) is a proinflammatory cytokine that is up-regulated in human myometrium during labor. Myometrium was collected from pregnant rats across gestation and at labor. Total RNA and...

the nonlinear budget set in the labor supply application, Figure A1 depicts a nonlinear budget set induced by a simple progressive tax. The after-tax wage, w, that a worker faces varies with the tax rate, t.2 The labor supply application examines the effect of the after-tax wage (the slope) on hours (the horizontal axis) controlling for income (the vertical axis). Similarly, I examine the effec...

We estimate a semiparametric dynamic panel data model by the local linear kernel method and we interpret the slope of the nonparametric component function as a varying slope coefficient. Thus, the slope coefficient is a smooth, but otherwise unknown, function of some of the regressors. A Monte Carlo experiment is reported to examine the finite sample performance of the local linear estimator. W...

Preterm labor is defined as the presence of regular uterine contractions with progressive cervical changes before 37 completed weeks of pregnancy. Spontaneous preterm labor accounts for 40% to 50% of all preterm births [1]. An estimated 13 million babies (−10% of all births) are born preterm each year worldwide, and approximately 1 million of all newborn deaths are due to preterm birth [2]. At ...