BACKGROUND/AIMS In our earlier study, indomethacin potentiated α7 acetylcholine (ACh) receptor responses by activating protein kinase C (PKC). The present study was conducted to gain further insight into the indomethacin action on PKC. METHODS PKC activity was assayed in PC-12 cells or under the cell-free conditions. PKC-ε was knocked-down using the siRNA to silence the PKC-ε-targeted gene. A...

Indomethacin, a nonsteroidal antiinflammatory agent which inhibits prostaglandin biosynthesis, is an effective inhibitor of mammary carcinogenesis in rats. However, the activity of indomethacin as a chemopreventive agent is limited by toxicity. The present studies were conducted to determine if the toxic and anticarcinogenic effects of indomethacin can be modified by the phenolic antioxidant, b...

Indomethacin is a widely used nonsteroidal anti-inflammatory drug. We studied the human cytochrome P450 (CYP) isoform responsible for indomethacin O-demethylation, the major metabolic pathway for indomethacin. For indomethacin O-demethylase activities, the KM value was 34.6 +/- 5.4 muM and the Vmax value was 14.1 +/- 3.9 pmol/mg/min in human liver microsomes (N = 4). Indomethacin O-demethylase ...

AIMS We investigated the effect of several Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), on the preoptic nerve oxygen tension (ONPO2), as indomethacin previously has demonstrated a strong decreasing effect on ONPO2. We tested whether these NSAIDs, like indomethacin, also reduce the increasing effect of dorzolamide on ONPO2. METHODS ONPO2 was measured 0.5 mm above the optic disc in 23 domest...

Aim. The side effects associated with the use of indometacin are noted by about 30-60% patients, therefore, in this context problem adverse event rate reduction is still relevant today. Cryopreserved placental extract (CEP) attracted our attention as a means pathogenetic correction ulcerogenic action indomethacin. aim paper to characterize antiulcer activity cryopreserved placenta on model indo...

OBJECTIVE The objective of this study was to evaluate the extent of renal adverse effects caused by ibuprofen or indomethacin in order to choose the safer drug to administer to preterm infants. METHODS THE FOLLOWING THREE PARAMETERS OF RENAL FUNCTION WERE TAKEN INTO CONSIDERATION: 1) the urine output; 2) the serum creatinine concentration; and 3) the frequency of oliguria. The bibliographic s...

PURPOSE There has been an ongoing increase in the frequency and severity of blunt chest injuries. Their rather high lethality is caused by the injury alone as well as by the following systemic inflammatory response. The aim of the study is to verify the efficacy of the pharmacological blockade of the systemic inflammatory response syndrome (SIRS) in serious blunt chest injuries, and to identify...

In this study, we examined the effect of nimesulide and ranitidine on the indomethacin- and ibuprofen-induced ulcer. In addition, we investigated whether there was a direct chemical interaction of nimesulide and ranitidine with indomethacin, and also whether nimesulide and ranitidine neutralized the gastric acid in vitro. Our studies showed that nimesulide (100, 300, 500 mg/kg) prevented the in...

background & aim:  non-steroidal anti-inflammatory drugs (nsaids) are commonly used in clinical medicine. the adverse effects they produce in the gastrointestinal tract however, often limit their utility. oxidative stress has been shown to occur in the small intestine in response to the oral administration of indomethacin. in view of this, the effect of thyme essential oil, an agent with an...

background: data suggest that v. arctostaphylos, b. thunbergii var. atropurpurea, e. angustifolia and l. acanthodes may prevent gastric ulcers induced by non-steroidal anti-inflammatory drugs (nsaids). objective: to explore the ulcer-protective potential of these plants in indomethacin-induced gastric ulcers in rats. methods: saline, hydro-alcoholic extract of each plant (100, 400, 800 mg/kg) a...