Human serum albumin (HSA) is the most abundant protein in the blood plasma. Drug binding to HSA is crucial to study the absorption, distribution, metabolism, efficiency and bioavailability of drug molecules. In this study, isothermal titration calorimetry and molecular dynamics simulation of HSA and its complex with indometacin (IM) were performed to investigate thermodynamics parameters and th...

It is estimated that nearly 12% of infants born weighing less than 1500 g will develop NEC and about 30% of these infants will not survive. [4] More than 85% of all NEC cases occur in infants of very low birth weight or in very premature infants. [5]Full-term and near-term infants also develop the disease. Patent ductus arteriosus is a risk factor in premature babies, especially if conservative...

It is estimated that nearly 12% of infants born weighing less than 1500 g will develop NEC and about 30% of these infants will not survive. [4] More than 85% of all NEC cases occur in infants of very low birth weight or in very premature infants. [5]Full-term and near-term infants also develop the disease. Patent ductus arteriosus is a risk factor in premature babies, especially if conservative...

A series of five-membered heterocyclic rings were synthesized by the reaction between benzoyl chloride and various chlolro-nitro-benzoyl chlorides and semi carbazide to form (C1- C7) compounds and was tested for their anti-inflammatory activity determined by rat-paw-oedema method. All the synthesis compounds have been characterized by (1)HNMR, IR and Mass spectral data. The compounds were purif...

In the present study we have determined some characteristics (aspect, odor, solubility, emulsion type, water and volatile substances content, total fatty matter, saponification index, ester index) for three pharmaceutical ointments belonging to the group of non-steroidal anti-inflammatory: Diclac, Ketonal, Indometacin and one antibiotic ointment for ophthalmic use: Ophtagram. In order to achiev...

It is estimated that nearly 12% of infants born weighing less than 1500 g will develop NEC and about 30% of these infants will not survive. [4] More than 85% of all NEC cases occur in infants of very low birth weight or in very premature infants. [5]Full-term and nearterm infants also develop the disease. Patent ductus arteriosus is a risk factor in premature babies, especially if conservative ...

Fourteen anovulatory postpartum (38.0 +/- 1.9 d) beef cows that ovulated after an injection of 250 micrograms gonadotropin releasing hormone (GnRH) in saline were used to examine the influence of indomethacin on luteal function. Beginning the d after GnRH, 6 cows were given intrauterine infusions of indomethacin for 14 d and the other eight cows received vehicle. After GnRH treatment, concentra...

Objective of present study involves preparation and evaluation of floating microballoons of indometacin as a model drug, to increase its residence time in the stomach without contact with the mucosa. The microballoons were prepared by the emulsion solvent diffusion technique using different ratio of acrylic polymers (Eudragit RS100 and Eudragit S 100) as carriers. The yield of microballoons was...