This pilot study was aimed at comparing TLR7/TLR9 expression, cytoskeletal arrangement, and cell proliferation by indirect immunofluorescence in parallel lesional non skin samples of guttate psoriasis (PG) vulgaris (PV) five male patients for each group (n=10). TLR7 expression detected throughout all the epidermal compartment PV samples, while PG restricted to granular layer. TLR9 present layer...

Human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs) have been shown as the most potential stem cell source for articular cartilage repair. In this study, we aimed to develop a method for long-term coculture of human articular chondrocytes (hACs) and hUCB-MSCs at low density in vitro to determine if the low density of hACs could enhance the hUCB-MSC chondrogenic differentiation...

Recent research has revealed relationship between cybervictimization and cyberbullying, but the possible role of anger as a mediating factor between cybervictimization and cyberbullying remains an area for further clarification. The purpose of this study was to analyze the direct and indirect relationships among cybervictimization, anger expression styles, and cyberbullying, and to test whether...

The gene expression control by DNA-binding drugs is of great interest in molecular biology and biotechnology. The ability of some drugs to switch on or off the gene expression brings the possibility to develop treatments for genetic diseases, infection by antibiotic-resistant bacteria, or cancer. The analysis of the DNA sequence-dependent conformational energy gives hints for the design of DNAb...

introduction: hepatitis c virus (hcv) infection is a major public health problem which influences about 170 million people worldwide. different types of vaccines have been designed using hcv structural proteins to control the viral infection. the core nucleocapsid protein is one of the most conserved proteins and a desirable target for hcv vaccines, especially the protein-based vaccines. in cur...

Synaptic modifications in nucleus accumbens (NAc) medium spiny neurons (MSNs) play a key role in adaptive and pathological reward-dependent learning, including maladaptive responses involved in drug addiction. NAc MSNs participate in two parallel circuits, direct and indirect pathways that subserve distinct behavioral functions. Modification of NAc MSN synapses may occur in part via changes in ...