INTRODUCTION Bisphosphonates have been shown to reduce osteoclastic activity and enhance pin fixation in both experimental and clinical studies. In this prospective, randomized study of high tibial osteotomy using the hemicallotasis (HCO) technique, we evaluate whether treatment by one single infusion of zoledronic acid can enhance the pin fixation. MATERIALS AND METHODS 46 consecutive patien...

Prefoldin is a molecular chaperone complex that regulates tubulin function in mitosis. Here, we show that Prefoldin depletion results in disruption of neuroblast polarity, leading to neuroblast overgrowth in Drosophila larval brains. Interestingly, co-depletion of Prefoldin and Partner of Inscuteable (Pins) leads to the formation of gigantic brains with severe neuroblast overgrowth, despite tha...

In friction stir welding frictional heat is generated by the rotating tool, sliding over the stationary plate along the weld centre. Tool being the only source of heat producing member, its geometrical design influences the heat generation rate. In this present work, effects of variation in tool shoulder and tool pin taper angles on thermal history during joining are analysed. Tools with triang...

The mechanical properties of Z-pins reinforced composites adhesively bonded single-lap joints (SLJs) under un-directional tension loading are investigated by experimental and numerical methods. Three kinds joint configurations, including SLJs with three/two rows “I” array Z-pins, test. failure modes mechanism different numbers alignment analyzed, the comparison is performed for strengths no joi...

In this article, we provide the first comprehensive study of user-chosen four- and six-digit PINs ( n =1705) collected on smartphones with participants being explicitly primed for device unlocking. We find that against a throttled attacker (with 10, 30, or 100 guesses, matching smartphone unlock setting), using instead four-digit provides little to no increase in security surprisingly may even ...

SU-8 can be patterned with high resolution, is flexible and tough. These characteristics qualify SU-8 as a material for making spotting pins for printing DNA and protein microarrays, and it can potentially replace the commonly used silicon and steel pins that are expensive, brittle in the case of silicon and can damage the substrate during the printing process. SU-8, however, accumulates large ...

Wen-Pin Hsieh,1,2,* Mark D. Losego,3 Paul V. Braun,2,3 Sergei Shenogin,4 Pawel Keblinski,4 and David G. Cahill2,3 1Department of Physics, University of Illinois, Urbana, Illinois 61801, USA 2Frederick-Seitz Materials Research Laboratory, University of Illinois, Urbana, Illinois 61801, USA 3Department of Materials Science and Engineering, University of Illinois, Urbana, Illinois 61801, USA 4Depa...

This work concerns the stress-state identification, produced by loads or dislocations, of statically indeterminate structures. In particular, this paper deals with the case of pin-jointed trusses, since they are a combination of simplicity of the structural model with very interesting technical applications. We present an approach that follows the main guidelines of the flexibility method to re...

Different PIN-FORMED proteins (PINs) contribute to intercellular and intracellular auxin transport, depending on their distinctive subcellular localizations. Arabidopsis thaliana PINs with a long hydrophilic loop (HL) (PIN1 to PIN4 and PIN7; long PINs) localize predominantly to the plasma membrane (PM), whereas short PINs (PIN5 and PIN8) localize predominantly to internal compartments. However,...