نتایج جستجو برای: in silico tools

تعداد نتایج: 17001493  

Journal: :journal of family and reproductive health 0
mohammad karimian gametogenesis research center, kashan university of medical sciences, kashan, iran hossein nikzad gametogenesis research center, kashan university of medical sciences, kashan, iran abolfazl azami-tameh anatomical sciences research center, kashan university of medical sciences, kashan, iran aliakbar taherian gametogenesis research center, kashan university of medical sciences, kashan, iran fatemeh zahra darvishi department of biology, division of biochemistry, cell and molecular biology, university of isfahan, isfahan, iran mohammad javad haghighatnia gametogenesis research center, kashan university of medical sciences, kashan, iran

objective: to investigate the association of c631t single nucleotide polymorphisms in spo11 gene with male infertilityfollowed by an in silico approach. spo11 is a gene involved in meiosis and spermatogenesis process, which in humans, this gene is located on chromosome 20 (20q13.2-13.3) with 13 exons. materials and methods: in a case-control study, 200 blood samples were collected from the ivf ...

پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه زابل - دانشکده علوم پایه 1393

گیرنده جفت شده پروتئین g 119 (gpr 119) یک هدف جالب و امیدوارکننده برای درمان بیماری دیابت نوع 2 (t2dm) است. در این تحقیق، روابط کمّی ساختار- فعالیت سه بعدی، الحاق کردن مولکولی و غربالگری مجازی بر روی یک سری از آگونیست های جدید gpr 119 انجام شد. نتایج، توانایی پیش بینی و قابلیت اطمینان بالایی از مدل ها را نشان داد. یک مدل فارماکوفوری کیفی با استفاده از الگوریتم hip-hop ساخته شد. این مدل رضایت بخش...

Journal: :Advanced drug delivery reviews 2015
Mark Hewitt Claire M Ellison Mark T D Cronin Manuel Pastor Thomas Steger-Hartmann Jordi Munoz-Muriendas Francois Pognan Judith C Madden

The use of in silico tools within the drug development process to predict a wide range of properties including absorption, distribution, metabolism, elimination and toxicity has become increasingly important due to changes in legislation and both ethical and economic drivers to reduce animal testing. Whilst in silico tools have been used for decades there remains reluctance to accept prediction...

, ,

Risk assessment of a transgene is one of the key steps in genetic transformation. Hence, in order to use cryIAc gene for production of transgenic plants, a library and in-silico research was performed to confirm safety of the gene for human comsumption, animal feed and environment. In the first step, the molecular mechanism of action of the CryIAc protein and its specific receptors in the midgu...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید