نتایج جستجو برای: immunosuppressive drug

تعداد نتایج: 607565  

Journal: :Immunopharmacology and immunotoxicology 2009
Brigitta Rumberger Clemens Kreutz Christian Nickel Marinella Klein Severine Lagoutte Sven Teschner Jens Timmer Peter Gerke Gerd Walz Johannes Donauer

Following organ transplantation many patients suffer from drug-related side effects, or receive more immunosuppression than necessary to prevent rejection. Hence, parameters are needed to tailor the immunosuppressive therapy to the individual needs of an organ recipient. The aim of this study was to determine whether drug combinations provoke specific gene expression patterns in a simple assay ...

Journal: :Pharmacogenomics 2016
Lucie Pouché Jana Stojanova Pierre Marquet Nicolas Picard

Interindividual variability in immunosuppressive drug responses might be partly explained by genetic variants in proteins involved in the immune response or associated with IS pharmacodynamics. On a general basis, the pharmacogenetics of drug target proteins is less known and understood than that of proteins involved in drug disposition pathways. The aim of this review is to facilitate research...

2015
Yi Li Lugen Zuo Weiming Zhu Jianfeng Gong Wei Zhang Lili Gu Zhen Guo Lei Cao Ning Li Jieshou Li Yung-Hsiang Chen.

We conducted a study to evaluate the impact of the exclusive enteral nutrition (EEN) on perioperative outcome in Crohn's disease (CD) patients following immunosuppressive therapy. Patients with CD followed at a referral center between January 2001 and March 2014 who underwent abdominal surgery were identified. Patients were divided into 4 groups: patients not exposed to immunosuppressive agents...

Journal: :iranian journal of basic medical sciences 0
niloufar mohammadpour department of microbiology, school of medicine, islamic azad university, mashhad branch, mashhad, iran zakariya research centre, islamic azad university, mashhad branch, mashhad, iran sepideh elyasi department of pharmacodinamy and toxicology, school of pharmacy, mashhad university of medical sciences, mashhad, iran naser vahdati department of pharmacodinamy and toxicology, school of pharmacy, mashhad university of medical sciences,mashhad, iran amir hooshang mohammadpour department of pharmacodinamy and toxicology, school of pharmacy, mashhad university of medical sciences,mashhad, iran pharmaceutical research centre, mashhad university of medical sciences, mashhad, iran

immunosuppressants require therapeutic drug monitoring because of their narrow therapeutic index and significant inter-individual variability in blood concentrations. this variability can be because of factors like drug-nutrient interactions, drug-disease interactions, renal-insufficiency, inflammation and infection, gender, age, polymorphism and liver mass. drug monitoring is widely practiced ...

Journal: :The Journal of pharmacology and experimental therapeutics 2001
D Hammond-McKibben P Lake J Zhang N Tart-Risher R Hugo M Weetall

We describe a high-capacity in vivo assay to measure drug-mediated transplant immunosuppression using a mouse model of Sa1 tumor rejection. Sa1 grew poorly and was rejected by 14 days in immunocompetent allogeneic recipient mice. In nude (nu/nu) mice, Sa1 grew more rapidly and was not rejected, confirming the T cell dependence of this response. In immunocompetent animals, administration of immu...

2018
JooYeon Jhun Seung Hoon Lee Soon Kyu Lee Hee Yeon Kim Eun Sun Jung Dong Goo Kim JeongWon Choi Si Hyun Bae Seung Kew Yoon Byung Ha Chung Chul Woo Yang Mi-La Cho Jong Young Choi

Recipients of liver transplantation (LT) require long-term immunosuppressive drug treatment, but lifelong immunosuppressive treatment has severe side effects. It is known that some LT recipients develop immune tolerance, and although the development of such operational tolerance should allow a decrease in the burden of immunosuppressive drug treatment, the factors that indicate operational tole...

Journal: :iranian journal of public health 0
n. mohagheghpour lk. nafici

the immunosuppressive effect of antimacrophage serum (ams) on the primary immune response of mice to sheep red blood cells (srbc) was studied. ams, given before a small dose of antigen, abrogated the immune response. transplantation of normal, galss-adherent macrophages enabled ams-treated animals to respond to srbc, while administration of lymph node lymphocytes did not reveres ams - induced i...

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