Immunological mechanisms play the leading role in pathogenesis of inflammatory destructive processes periodontium. That's why clinical manifestations chronic generalized periodontitis depend not so much on pathogenicity and virulence corresponding microflora but character bacterial-gostal interrelations, that is, many respects - degree macroorganism reactivity, which is determined by functional...

The present study aimed to determine the effects of lucantin red and yellow and also astaxanthin on the growth, hematological and immunological parameters, and coloration of the tiger oscar (Astronotus ocellatus). To this end, 120 fingerlings of tiger oscar were equally and randomly divided into 12 aquariums. The fish were fed with experimental diets for 8 weeks. Treatments included diets conta...

Background: Despite years of continuous research, maternal mortality due to preeclampsia is still a serious threat. Researchers believe that preeclampsia is a multifactorial disease and proposed many risk factors including immunological factors for it. Given the description of preeclampsia as an excessive response of the immune system, the relationship between preeclampsia and immunological cha...

DNAX accessory molecule 1 (DNAM-1) is expressed on all CD8(+) T cells and promotes their activation and effector function. DNAM-1 interacts with LFA-1, a critical molecule for immunological synapse formation between T cells and APCs, and for cytotoxic killing of target cells. Mice that lack DNAM-1 display abnormal T cell responses and antitumor activity; however, the mechanism involved is uncle...

The activation of biological T cell responses requires prolonged contact with APCs and sustained signaling. We investigated whether signaling must be uninterrupted to commit T cells to cytokine production or whether T cell activation may also result from summation of interrupted signals. Upon periodic addition and removal of a src kinase inhibitor, human CD4(+) T cells destroyed and re-formed i...