PURPOSE Immuno-positron emission tomography (PET), the combination of PET with monoclonal antibodies (mAb), is an attractive option to improve tumor detection and to guide mAb-based therapy. The long-lived positron emitter zirconium-89 ((89)Zr) has ideal physical characteristics for immuno-PET with intact mAbs but has never been used in a clinical setting. In the present feasibility study, we a...

Developers of cancer immunotherapy have struggled for decades to achieve clinical success in using the patient's immune system to treat cancer. In the absence of a defined development paradigm for immunotherapies, conventional criteria established for chemotherapy were applied to these agents. This article summarizes the recent lessons for development of agents in the immunotherapy space, descr...

Although the advent of new immunotherapy approaches has improved survival for many patients with advanced malignancies, the high degree of nonresponders, especially in highly prevalent malignancies including breast, colon and prostate cancers was also a strong reminder that we possess only partial understanding of the events underlying the immune resistance of tumors. Considerable evidence indi...

BACKGROUND Predictors of immuno-virologic outcomes and discordance and their associations with clinical, demographic, socio-economic and behavioral risk factors are not well described in Nigeria since HIV viral load testing is not routinely offered in public HIV treatment programs. METHODS The HACART study was a multi-center observational clinic-based cohort study of 2585 adults who started H...

We have developed an immuno-polymerase chain reaction protocol which includes a highly purified streptavidin-DNA conjugate. The protocol comprises standard ELISA methodology and washing buffers together with a real-time PCR read-out system. The conjugate was employed in both indirect and capture assay formats, which can be completed in a single day using standard laboratory equipment. The immun...

The primary objective of this article is to introduce an immuno-epidemiological model of paratuberculosis (Johne’s disease). To develop the immuno-epidemiological model, we first develop an immunological model and an epidemiological model. Then, we link the two models through time-since-infection structure and parameters of the epidemiological model. We use the nested approach to compose the im...

Psoriasis is a chronic, recurrent, immuno-inflammatory disease of the skin and joints associated with significant morbidity and mortality. Psoriasis affects approximately 2-4% of the Caucasian population worldwide. The precise immuno-inflammatory mechanisms leading to skin psoriasis are still to be fully defined. There is emerging evidence supporting the existence of a relationship between chan...

Stress is known to suppress or dysregulate immune function and increase susceptibility to disease. Paradoxically, the short-term fight-or-flight stress response is one of nature's fundamental defense mechanisms that galvanizes the neuroendocrine, cardiovascular, and musculoskeletal systems into action to enable survival. Therefore, it is unlikely that short-term stress would suppress immune fun...

Abbreviations used are: ~, about; α, anti-; ∆, delta (deletion); Ab or Abs, antibody or antibodies; Cav-1, caveolin-1; CS, cigarette smoke; EDAC, 1-Ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride; EGF, epidermal growth factor; EGFR, epidermal growth factor receptor; H2O2, hydrogen peroxide; HAE, human airway epithelial; HRP, horseradish peroxidase; IB, or IBed, immuno-blotting or imm...