Malignant syphilis is considered a rare disease, more commonly affecting individuals with poor immunity. We report case of acquired immune deficiency syndrome (AIDS) repeated crusted ulcerat...

Primary immune deficiency diseases arise due to heritable defects that often involve signaling molecules required for immune cell function. Typically, these genetic defects cause loss of gene function, resulting in primary immune deficiencies such as severe combined immune deficiency (SCID) and X-linked agammaglobulinemia (XLA); however, gain-of-function mutations may also promote immune defici...

Considering the COVID-19 pandemic, vitamin D is a target of research and speculation. Lockdown or home isolation reduces sunlight exposition increases risk deficiency. Special attention needed for older people at both severe forms This review aims to highlight association in two instances, direct influence on immune system, indirect risks other deficiency-related diseases, such as musculoskelet...