Liposomal amphotericin-B (AmBisome) is now becoming first choice for the treatment of visceral leishmaniasis (kala-azar) patients due to high efficacy and less toxicity. The reported incidence of hypersensitivity reactions to liposomal amphotericin-B (AmBisome), especially during therapy, is very rare. We report two patients with kala-azar: one developed breathing difficulties and hypotension f...

Mast cells are resident effector cells, which are essential for the elicitation of the allergic response of immediate type. However, the release and significance of different mast cell mediators in the allergic wheal reaction are poorly understood, except for histamine. Therefore, in this study the involvement of mast cell mediators in the allergic prick test wheal induced by cow and bee allerg...

INTRODUCTION In spite of the wide usage of corticosteroids for the treatment of a plethora of diseases, sometimes they can induce immediate hypersensitivity reactions, which are however uncommon. CASE OUTLINE We report a case of immediate allergic reaction induced by intravenous methylprednisolone given before operation for surgical repair of an arm contracture as a sequel of burns, which the...

BACKGROUND Maltitol is a sugar alcohol that is frequently used as a noncaloric sweetener, although it is also used as an excipient, a plasticizer in gelatin capsules, and an emollient. It has not been previously described as an agent involved in immediate hypersensitivity reactions. METHODS We report on an anaphylactoid reaction with pharyngeal occlusion suffered by a 60-year-old man after in...

It has been shown that the polymers GLA5, GLT, GLA40, and GLAT are antigenic in human beings. Both immediate skin reactions and delayed (cellular) reactions were observed. The antibody produced reacted well in the precipitin reaction, agglutinated antigen coated tanned sheep cells, was less effective in inducing PCA reactions, and failed to sensitize guinea pigs for passive systemic anaphylaxis...

The objectives of this study are 1) To review the published data and document the current knowledge on allergic manifestations to the fruit mango 2) To highlight the two distinct clinical presentations of hypersensitivity reactions caused by mango 3) To discuss the role of cross-reactivity 4) To increase awareness of potentially life threatening complications that can be caused by allergy to ma...

The right eyes of guinea pigs were injected with 1.5 mg sterile ovalbumin. Two months later, one drop of ovalbumin (approximately 0.6 mg) was applied to the conjunctiva of both eyes. All challenged eyes developed an immediate hypersensitivity reaction within 5 min. The reaction subsided within 2 hrs. Prechallenge antibody titers, as determined by passive hemagglutination, passive cutaneous anap...

Sixty-nine children with moderately severe perennial asthma were submitted to bronchial provocation tests using aqueous extracts of Dermatophagoides pteronyssinus (house dust mite). 60 (87%) had immediate positive reactions. 73% also had late reactions occurring 4 to 8 hours after the challenge. A significant correlation was found between frequent attacks of asthma in the year before bronchial ...