The aggressiveness of melanoma is believed to be correlated with tumor-stroma-associated immune cells. Cytokines and chemokines act to recruit and then modulate the activities of these cells, ultimately affecting disease progression. Because melanoma frequently metastasizes to the brain, we asked whether global differences in immunokine profiles could be detected in the cerebrospinal fluid (CSF...

With the widespread use of radio-frequency devices, it is increasingly important to understand the biological effects of the associated electromagnetic fields. Thus, we investigated the effects of radio-frequency electromagnetic fields (RF-EMF) on T cell responses during development due to the lack of science-based evidence for RF-EMF effects on developmental immune systems. Sprague Dawley (SD)...

The T helper type 2 (Th2) cytokine genes Il4, Il5, and Il13 are contained within a 140-kb region of mouse chromosome 11 and their expression is controlled by a locus control region (LCR) embedded within this locus. The LCR is composed of a number of DNase I-hypersensitive sites (HSs), which are believed to encompass the regulatory core of the LCR. To determine the function of these sites, mutan...

Vitamin D has been recognized for its immune-modulating properties. We have previously found that levels of 25OHD, and cytokines including IL5, IFNα2, and TNFα, are also associated with estrogen receptor (ER) negative breast cancer in younger women. Thus, we hypothesized that there may be interactions between vitamin D and the immune system in influencing breast cancer ER status, which was test...

Background Eosinophilic granulomatosis with polyangiitis (EGPA), formerly Churg-Strauss syndrome, is a rare type of anti-neutrophil cytoplasm antibody-associated vasculitis, associated asthma, nasal poliposis and rinosinusitis, in which eosinophils play key role. Eosinophil targeted therapies alone or to conventional treatment corticosteroids immunosuppressant drugs may be useful patients refra...

The contribution of the intermediate vector boson to the muon anomalous moment is calculated in the 5 -limiting formalism. We find AK P = (&8x2) (il5/%)“[2 (1 K w) h 5 + 7,3] where &( g,/s)2 = GF is the Fermi weak coupling constant and KW is the W anomalous moment. For K W = 0, and 6 chosen according to the prescription of Lee, this contribution is numerically -8 N 3 AK N1.0 x 10 P _ 0.8 t . ( ...

subjects gave their informed consent to obtain samples. Tear and Serum Samples were collected to determine cytokines IL2, IL-4, IL-5, IFN-g, TNF-a, IL-10 by cytometric bead arrays (CBA), following manufacturer’s instructions. Results: Patients showed lower significant levels of L-4 after 6 months of treatment, without changes in IL2, IL5, TNFa and IL10. Significant Clinical improvement was also...

Rheumatoid arthritis (RA) is a disease well characterised by proinflammatory cytokine secretion (particularly tumour necrosis factor, interferon gamma, interleukin (IL) 1, and IL6). Less has been reported about the cytokine profiling in the spondyloarthropathies (SpA). Several trials suggest that, similar to RA, proinflammatory cytokines are globally expressed in the SpA. However, other studies...

We describe the system our team used during NIST’s LoReHLT (Low Resource Human Language Technologies) 2017 Evaluations, which evaluated document topic classification. We present a language agnostic approach combining universal acoustic modeling, evaluation-language-to-English machine translation (MT) and an English-language topic classifier. This combination requires no transcribed speech in th...