Inflammation is necessary for immune defense against pathogens and a functional antitumor response, but chronic inflammation promotes tumor growth enables tumors to escape from immune-mediated destruction. Recently, we others demonstrated that deficiency of IL1β strongly favors immunity, multiple clinical trials involving antibody mediated blockade in cancers are underway. The mechanism, howeve...

Abstract Type 2 diabetic (T2D) wound Macrophages (Mϕs) display a delayed chronic inflammatory state that prevents the resolution of inflammation. Increased NLRP3 inflammasome gene expression and activation in Mϕs contributes to impaired healing T2D is induced by environment factors, yet molecular mechanisms regulating this are unclear. Our lab has shown keratinocytes regulate Mϕ phenotype durin...

Abstract Pancreatic ductal adenocarcinoma (PDAC) is a deadly malignancy characterized by poor response to all existing therapies. Although immunotherapy has shown great promise against multiple cancers, it been largely ineffective in PDAC. This lack of part attributed its extensive, fibroinflammatory stroma and hypoxic microenvironment. Cancer-associated fibroblasts (CAFs) are the predominant s...

Mekhanizm patogeneticheskogo utyazheleniya v sisteme SARS-CoV-2–essencial'noj gipertenzii (EAG) nosit bolee slozhnyj harakter, chem vzaimodejstvie na urovne angiotenzinprevrashchayushchego fermenta 2 (ACE2). Cel'yu issledovaniya bylo proanalizirovat' dinamiku soderzhaniya predstavitelej semejstva IL1 (IL1β, IL1α, IL1ra, IL18, IL18BP, IL37) krovi bol'nyh EAG cherez 10, 30 i 180 dnej posle COVID-...

OBJECTIVES Molecular events occurring in the bone marrow microenvironment of an immobilized mouse limb after Botulinum toxin (BTX) injection haven't been characterized. BTX injection induces a localized disuse in which the tissue events have well been characterized. METHODS BTX injection was performed in the right quadriceps; saline injection in the left side was used as control. Mice were sa...

BACKGROUND Severe asthma is a heterogeneous disease and the relationship between airway inflammation and airway remodelling is poorly understood. We sought to define sputum mediator profiles in severe asthmatics categorised by CT-determined airway geometry and sputum differential cell counts. METHODS In a single centre cross-sectional observational study we recruited 59 subjects with severe a...

Fisetin, a known antioxidant, has been found to be cytotoxic against certain cell lines. However, the mechanism by which it inhibits tumor growth in vivo remains unexplored. Recently, we have demonstrated that Aflatoxin-B1 (AFB1) induced hepatocarcinogenesis is associated with activation of oxidative stress-inflammatory pathway in rat liver. The present paper describes the effect of in vivo tre...

Diisocyanates are the most common cause of occupational asthma, but risk factors are not well defined. A case-control study was conducted to investigate whether genetic variants in inflammatory response genes (TNFα, IL1α, IL1β, IL1RN, IL10, TGFB1, ADAM33, ALOX-5, PTGS1, PTGS2 and NAG-1/GDF15) are associated with increased susceptibility to diisocyanate asthma (DA). These genes were selected bas...

West Nile virus (WNV) is one of the most common causes of epidemic viral encephalitis in horses worldwide. Peripheral blood mononuclear cells (PBMCs) are amongst the first to encounter the virus following a mosquito bite. This study aimed to elucidate the transcription kinetics of cytokine, Toll-like receptor (TLRs) and TLRs-associated genes following WNV challenge of equine PBMCs. PBMCs were c...

BACKGROUND To investigate possible differences in the effects of soluble factors from oral squamous cell carcinoma (SCC) cells (UT-SCC-87) and normal oral keratinocytes (NOK) on fibroblast expression of genes involved in tumor stroma turnover. MATERIALS AND METHODS Transwell co-cultures with fibroblasts in collagen gels, and SCC cells or NOK in inserts were carried out. Fibroblast gene expres...