نتایج جستجو برای: ii bcl2

تعداد نتایج: 584067  

پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه علم و فرهنگ - پژوهشکده رویان 1388

مقدمه : فراگمنتاسیون پدیده ی شایعی است که در بیش از ??% جنین های انسانی که در محیط کشت آزمایشگاهی رشد می کنند مشاهده می شود. یکی از مکانیسم های فراگمنتاسیون، آپوپتوز می باشد. در این مطالعه به منظور دستیابی به ارتباط میان آپوپتوز و فراگمنتاسیون، نقش متیلاسیون dna را در مهار بیان ژن های آنتی و پرو آپوپتوز بررسی می کنیم. روش ها: با استفاده از میکروسکوپ معکوس و بر اساس درجه فراگمنتاسیون، جنین های ا...

Journal: :Autophagy 2012

2013
Inga Karch Elisa Schipper Henriette Christgen Hans Kreipe Ulrich Lehmann Matthias Christgen

Inactivation of CDH1, encoding E-cadherin, promotes cancer initiation and progression. According to a newly proposed molecular mechanism, loss of E-cadherin triggers an upregulation of the anti-apoptotic oncoprotein BCL2. Conversely, reconstitution of E-cadherin counteracts overexpression of BCL2. This reciprocal regulation is thought to be critical for early tumor development. We determined th...

Journal: :The Journal of biological chemistry 1998
P P Ruvolo X Deng B K Carr W S May

Phosphorylation of Bcl2 at serine 70 may result from activation of a classic protein kinase C (PKC) isoform and is required for functional suppression of apoptosis by Bcl2 in murine growth factor-dependent cell lines (Ito, T., Deng, X., Carr, B., and May, W. S. (1997) J. Biol. Chem. 272, 11671-11673). Human pre-B REH cells express high levels of Bcl2 yet remain sensitive to the chemotherapeutic...

Journal: :Journal of Cutaneous Pathology 2021

Primary cutaneous follicle center lymphoma (PCFCL) is the most common B-cell lymphoma. The typical immunophenotype includes expression of both CD20 and BCL6, with majority cases lacking CD10, BCL2, characteristic t(14;18)/IGH-BCL2 rearrangement seen in systemic follicular (FL). Plasmacytic differentiation (PD) an uncommon finding FLs presents a diagnostic challenge when present, leading to pote...

Journal: :Scientific reports 2016
Yuxia Zhang Chune Liu Olivier Barbier Rana Smalling Hiroyuki Tsuchiya Sangmin Lee Don Delker An Zou Curt H Hagedorn Li Wang

Bile acid (BA) metabolism is tightly controlled by nuclear receptor signaling to coordinate regulation of BA synthetic enzymes and transporters. Here we reveal a molecular cascade consisting of the antiapoptotic protein BCL2, nuclear receptor Shp, and long non-coding RNA (lncRNA) H19 to maintain BA homeostasis. Bcl2 was overexpressed in liver of C57BL/6J mice using adenovirus mediated gene deli...

Journal: :The Journal of biological chemistry 2007
Yongzhong Hou Fengqin Gao Qinhong Wang Jinfeng Zhao Tammy Flagg Yangde Zhang Xingming Deng

Bcl2 has been reported to suppress DNA mismatch repair (MMR) with promotion of mutagenesis, but the mechanism(s) is not fully understood. MutSalpha is the hMSH2-hMSH6 heterodimer that primarily functions to correct mutations that escape the proofreading activity of DNA polymerase. Here we have discovered that Bcl2 potently suppresses MMR in association with decreased MutSalpha activity and incr...

2015
M. SANKAR JOHANNA RAJKUMAR SRIDHAR

Objective: To evaluate the hepato protective role of Heptoplus (HP), a ployherbal formulation as a supplementary agent for the Isoniazid and Rifampicin induced oxidative stress and apoptosis in liver. Methods: Liver cell lines were divided in to five groups. Group I is control, group II is treated with 30ng/ml of INH+RIF, group III, IV and V are supplemented with 50, 100 and 200 ng/ml of HP. At...

Journal: :Blood 2007
Yoko Otake Sridharan Soundararajan Tapas K Sengupta Ebenezer A Kio James C Smith Mauricio Pineda-Roman Robert K Stuart Eleanor K Spicer Daniel J Fernandes

B-cell chronic lymphocytic leukemia (CLL) is characterized by the accumulation of clonal B cells that are resistant to apoptosis as a result of bcl2 oncogene overexpression. Studies were done to determine the mechanism for the up-regulation of bcl-2 protein observed in CD19+ CLL cells compared with CD19+ B cells from healthy volunteers. The 11-fold higher level of bcl-2 protein in CLL cells was...

Journal: :Blood 2004
Alexander Egle Alan W Harris Mary L Bath Lorraine O'Reilly Suzanne Cory

In human follicular lymphoma the t(14; 18) chromosome translocation activates the antiapoptotic oncogene Bcl2 by linking it to the immunoglobulin heavy chain (IGH) locus. Transgenic mice expressing Bcl2 controlled by an Igh enhancer (E mu) do not develop follicular lymphoma, although they do have an increased incidence of other B-lymphoid neoplasms. We have now analyzed tumorigenesis in mice be...

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