about the frequency of central and peripheral auditory system affection in 73 patients with a mitochondrial disorder (MID) due to mitochondrial DNA (mtDNA) point mutations or a single mtDNA deletion. We had the following comments and concerns. How can the authors be sure that impaired hearing (IH) was due to mtDNA‑mutations and not due to one of the frequent other genetic defects associated wit...

Most of the currently accepted designs for cryptographic hash functions are in the style of a block cipher in feed-forward mode. With increasing interest in all forms of cryptanalysis, this limited choice might become a single point of failure in computer security, and so we seek alternative paradigms. In this paper an entirely new approach, based on iterated halving (IH), is proposed for the d...

background many multimodal analgesia techniques have been tried to provide adequate analgesia for midline incisions extending above and below the umbilicus aiming at limiting the perioperative use of morphine thus limiting side effects. ultrasound (us) guidance made the anesthesiologist reconsider old techniques for wider clinical use. the rectus sheath block (rsb) is a useful technique under-u...

results totally, 20 patients completed the study. the cms and pain scores significantly improved after the block. conclusions the use of the modified lateral ssnb of feigl significantly reduces pain and increases shoulder function, in chronic shoulder pain. patients and methods patients were evaluated using the constant-murley score (cms) and number rating scale values for pain. the ssn was blo...

introduction: pain control is the most important issue in emergency department management of patients with femoral bone fractures. the present study aimed to compare the procedural features of ultrasonography and nerve stimulator guided femoral nerve block in this regard. method: in this randomized clinical trial, patients with proximal femoral fractures presenting to emergency department were ...

Obstructive sleep apnea causes chronic intermittent hypoxia (IH) and is associated with impaired glucose metabolism, but mechanisms are unknown. Carotid bodies orchestrate physiological responses to hypoxemia by activating the sympathetic nervous system. Therefore, we hypothesized that carotid body denervation would abolish glucose intolerance and insulin resistance induced by chronic IH. Male ...

background the aim of the present study was to compare two analgesic techniques for transrectal ultrasound (trus)-guided biopsy: diclofenac patch versus periprostatic nerve block with 1% lidocaine. objectives to study the efficacy of and compare diclofenac patch and periprostatic nerve block as analgesia in trus-guided prostate needle biopsy. patients and methods in total, 60 patients were pros...

Hyperpolarization-activated cation currents, termed If, Ih, or Iq, were initially discovered in heart and nerve cells over 20 years ago. These currents contribute to a wide range of physiological functions, including cardiac and neuronal pacemaker activity, the setting of resting potentials, input conductance and length constants, and dendritic integration. The hyperpolarization-activated, cati...

The hyperpolarization-activated inward cationic current (Ih) is known to regulate the rhythmicity, excitability, and synaptic transmission in heart cells and many types of neurons across a variety of species, including some pyloric and gastric mill neurons in the stomatogastric ganglion (STG) in Cancer borealis and Panulirus interruptus However, little is known about the role of Ih in regulatin...

introduction: pain is the most common complaint of patients referring to emergency department (ed). considering the importance of pain management in ed, this study aimed to investigate the efficacy and feasibility of ultrasound-guided nerve blocks in this setting. methods: 46 patients who came to the ed with injured extremities were enrolled in the study and received either femoral, axillary or...