نتایج جستجو برای: igvh mutation
تعداد نتایج: 291497 فیلتر نتایج به سال:
Ferrajoli and colleagues present the results of a phase 2 study in which lenalidomide was administered by continuous daily dosing to 44 patients with relapsed CLL. Clinical activity (ORR 32%, CR 7%) was observed, and responses were seen in patients with poor-risk cytogenetic abnormalities and unmutated IgVH. However, the mechanism(s) of action and the optimal dosing schedule of lenalidomide rem...
The immunoglobulin variable heavy chain (IgVH) gene mutation status is an important prognostic factor in chronic lymphocytic leukemia (CLL), since cases with mutated VH genes show significantly longer survival than unmutated cases. Recently, we reported a preferential use of the VH3-21 gene in mutated CLL and showed that mutated VH3-21 cases had an inferior overall survival compared with other ...
Submit Manuscript | http://medcraveonline.com Abbreviations: CLL: Chronic Lymphocytic Leukemia; FCR: Fludarabine, Cyclophosphamide and Rituximab; PI3K: Phosphatidylinositol 3-kinase; IWCLL: International Workshop on Chronic Lymphocytic Leukemia; CIRS: Cumulative Illness Rating Scale; CIT: chemoimmunotherapy; FISH: Fluorescence In Situ Hybridization; PFS: Progression Free Survival; EMA: European...
Chronic lymphocytic leukemia (CLL) is the most common leukemia of adults in Western countries. There are approximately 19 000 new cases diagnosed in the United States in 2016 (https://seer. cancer.gov/statfacts/html/clyl.html). MicroRNAs (miRs) have been implicated as one of the key contributors in the pathogenesis of CLL. One of these miRNAs is miR-155, which is probably the bestcharacterized ...
BACKGROUND AND OBJECTIVES Chemokine receptors are involved in tumor progression and several of these receptors, including CXCR3, are expressed by chronic lymphocytic leukemia (CLL) B cells. This study was aimed to examine a possible relationship between CXCR3 expression in CLL and the clinical evolution of the disease. DESIGN AND METHODS Using flow activated cell sorting (FACS), we analyzed t...
Human B lymphocytes expressing the CD5 surface antigen (CD5+ B cells) constitute a subset capable of producing polyspecific antibodies recognizing a variety of self antigens. The repertoire of antibodies produced by CD5+ and CD5- B cells is different. However, it is not yet established whether this distribution is reflected in different immunoglobulin variable region gene (IgV) use. Rearrangeme...
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