نتایج جستجو برای: igf binding protein i

تعداد نتایج: 2361947  

Journal: :Journal of applied physiology 2004
Dan Nemet Peter H Connolly Andria M Pontello-Pescatello Christie Rose-Gottron Jennifer K Larson Pietro Galassetti Dan M Cooper

Circulating IGF-I is correlated with fitness, but results of prospective exercise training studies have been inconsistent, showing both increases and decreases in IGF-I. We hypothesized that energy balance, often not accounted for, is a regulating variable such that training plus an energy intake deficit would cause a reduction in IGF-I, whereas training plus energy intake excess would lead to ...

Journal: :Protein engineering 2001
S Geddes P Holst J Grotzinger R Gill P Nugent P De Meyts A Wollmer S Wood J Pitts

The structure and biological activities of two disulphide isomers of a C-region deletion mutant of insulin-like growth factor-I (IGF-I) which has an Asn--Gly link engineered at the junction of the A- and B-regions were studied before and after chemical cleavage. Circular dichroism (CD) spectra and binding affinity to IGF binding protein 3 (IGFBP3) indicated that the treatment with hydroxylamine...

Journal: :American journal of physiology. Cell physiology 2009
R Andrew Shanely Kevin A Zwetsloot Thomas E Childs Simon J Lees Richard W Tsika Frank W Booth

IGF-I increases skeletal muscle mass, but whether IGF-I increases type IIb myosin heavy chain (MyHC) transcriptional activity is not known. C2C12 myotubes were cultured with or without IGF-I to determine whether IGF-I increases type IIb MyHC promoter activity, and if so, what region of the promoter might IGF-I signaling regulate. At differentiation days 3 and 4, IGF-I increased type IIb MyHC mR...

Journal: :International journal of experimental diabetes research 2002
Mogher Khamaisi Allan Flyvbjerg Ziv Haramati Gadi Raz Isaiah D. Wexler Itamar Raz

The metabolic aberrations associated with diabetes mellitus profoundly alter the growth hormone/insulin-like growth factor I (GH/IGF-I) system. In severe experimental diabetes, serum IGF-I level is reduced, reflecting altered hepatic expression. On the other hand, increased levels of kidney IGF-I have been implicated in the development of diabetic kidney disease. This study aimed to examine the...

Journal: :The Journal of nutrition 2010
Charles H Lang Christopher J Lynch Thomas C Vary

Acute alcohol intoxication decreases skeletal muscle protein synthesis by impairing mammalian target of rapamycin (mTOR). In 2 studies, we determined whether inhibition of branched-chain amino acid (BCAA) catabolism ameliorates the inhibitory effect of alcohol on muscle protein synthesis by raising the plasma BCAA concentrations and/or by improving the anabolic response to insulin-like growth f...

Journal: :The American journal of physiology 1999
K M Kelley T R Johnson J Ilan R W Moskowitz

Nonresponsiveness to the growth-stimulatory actions of insulin-like growth factor (IGF)-I in chondrocytes has been reported in a number of disease states associated with impaired glucose metabolism. Primary rabbit chondrocytes were investigated for changes in their IGF response system [type-I IGF receptor and IGF-binding protein (IGFBP) expression] and in their ability to mount a synthetic resp...

Journal: :Endocrinology 1992
A H Guse W Kiess B Funk U Kessler I Berg G Gercken

Cultured cardiac myocytes from adult Sprague-Dawley rats express both insulin-like growth factor-I (IGF-I) receptors and insulin-like growth factor-II/mannose 6-phosphate (IGF-II/Man6P) receptors and respond to IGF-I with a dose-dependent accumulation of inositol 1,4,5-trisphosphate [Ins(1,4,5)P3] and inositol 1,4-bisphosphate [Ins(1,4)P2]. Specific binding of [125I]IGF-I to isolated membranes ...

2011
Nicholas J. Skelton Michelle L. Schaffer Kurt Deshayes Tamas Blandl Steven Runyon Gerald Nakamura Sachdev S. Sidhu

Insulin-like growth factor-I (IGF-I) is a central mediator of cell growth, differentiation and metabolism. Structural characterization of the protein has been hampered by a combination of internal dynamics and self-association that prevent crystallization and produce broad NMR resonances. To better characterize the functions of IGF-I, we have used phage display to identify peptides that antagon...

Journal: :American journal of physiology. Gastrointestinal and liver physiology 2001
E M Zimmermann L Li Y T Hou N K Mohapatra J B Pucilowska

Insulin-like growth factor (IGF)-I and its binding protein IGF binding protein 5 (IGFBP-5) were highly expressed in inflamed and fibrotic intestine in experimental Crohn's disease. IGF-I induced proliferation and increased collagen synthesis by smooth muscle cells and fibroblasts/myofibroblasts in vitro. Here we studied IGF-I and IGFBP-5 in Crohn's disease tissue. Tissue was collected from pati...

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