Traditionally, immunoglobulin A (IgA) was thought to neutralize virus by forming complexes with viral attachment proteins, blocking attachment of virions to host epithelial cells. Recently we have proposed an intracellular action for dimeric IgA, which is actively transported through epithelial cells by the polymeric immunoglobulin receptor (pIgR), in that it may be able to bind to newly synthe...

INTRODUCTION IgA deficiency (IgAD) is the most common primary immunodeficiency, which can cause frequent infections. The association of IgA deficiency with systemic lupus erythematosus (SLE) is very important because of the high morbidity and mortality rates of infections in patients with this disease. OBJECTIVES To study the prevalence of IgA deficiency in SLE patients from southern Brazil a...

OBJECTIVES To determine the induction and changes in anti-influenza virus secretory IgA (s-IgA) levels in nasal washes and serum IgG levels in patients with influenza. METHODS The study recruited 16 patients with influenza aged 35.6 ± 9.6 years in 2007/2008 and 2008/2009 seasons. Nasal washes and serum were obtained throughout the first year. Anti-viral s-IgA levels and neutralization activit...

OBJECTIVE To examine gluten sensitivity through the measurement of anti-gliadin antibody (IgA and IgG), anti-endomysial antibody (endo-IgA), anti-reticulin antibody (IgG) and anti-transglutamase antibody (IgG) levels in blood samples of autistic in the Riyadh area. METHODS The study took place in the Department of Physiology, Faculty of Medicine, King Saud University, Riyadh between September...

BACKGROUND & AIMS To determine the prognostic potential of classic and novel serologic antibodies regarding unfavorable disease course in a prospective ulcerative colitis (UC) patient cohort, since few and conflicting data are available in the literature regarding this matter. METHODS 187 consecutive patients were studied prospectively (median follow-up: 135 months) from a single referral IBD...

Mice, greater than 20 wk old, were tested for the presence of anti-IgG autoantibodies by agglutination and radioimmunoassay. IgA and IgM anti-IgG were found in the 129/Sv, C57BL/6, and DBA/2 strains from the local colony at the International Institute of Cellular and Molecular Pathology (ICP), at the Institut Pasteur de Paris (IP), and in the endotoxin-resistant C3H/He strain of ICP. These stra...

tion or dapsone/sulfapyridine dose); however, future studies should attempt to correlate levels of IgA anti-eTG with parameters of disease activity, including degree and duration of gluten restriction, and dapsone/sulfapyridine dose. The patient presented in Table 2 shows that the levels of each Ab assay decreases over time with adherence to a gluten-free diet. Although definitive conclusions c...

By G. N. VYAS, L. HOLMDAHL, H. A. PERKINS AND H. H. FUDENBERG H UMAN ANTIBODIES to human gamma globulins are generally detected by agglutination of red cells coated with IgG, most often in the form of incomplete anti-Rh antiserum;’ normal and myeloma IgG proteins coated by bisdiazotized benzidine and chrornic chloride have also been used.2” These passive hernagglutination methods are applied to...

By G. N. VYAS, L. HOLMDAHL, H. A. PERKINS AND H. H. FUDENBERG H UMAN ANTIBODIES to human gamma globulins are generally detected by agglutination of red cells coated with IgG, most often in the form of incomplete anti-Rh antiserum;’ normal and myeloma IgG proteins coated by bisdiazotized benzidine and chrornic chloride have also been used.2” These passive hernagglutination methods are applied to...