نتایج جستجو برای: ift
تعداد نتایج: 953 فیلتر نتایج به سال:
The Image Foresting Transform (IFT) is a powerful graph-based framework for the design and implementation of image processing operators. In this work we present the Partitioned IFT (PIFT), an algorithm that computes any IFT operator as a series of independent IFT-like computations. The PIFT makes parallelization of existing IFT operators easy, and allows the computation of IFTs in systems with ...
Intraflagellar transport (IFT) is the bidirectional transport of multisubunit protein complexes, called IFT particles, along axonemal microtubules (MTs) beneath the ciliary membrane. IFT plays essential roles in the assembly and function of cilia and flagella by contributing to cell motility, sensory perception and ciliumbased signaling (Rosenbaum and Witman, 2002; Scholey, 2003). IFT was first...
سابقه و هدف: سندرم (کریز) کولینرژیک عارضه بسیار خطرناک داروهای آنتی کولین استراز، چون نئوستگمین است. برای بررسی بیداری حین بیهوشی که خود مسئله ای قابل تامل در بیهوشی مخدری (Anesthesia Narcotic Based) است از روش جداسازی ساعد (IFT) با تزریق نئوستگمین استفاده می شود. روش مذکور همچنین در ارزیابی ایسکمی شریان نخاعی قدامی و در بررسی بروز ضعف عضلات حرکتی اندام فوقانی بدنبال جراحی ستون مهره های گردنی م...
BACKGROUND Bidirectional intraflagellar transport (IFT) consists of two major protein complexes, IFT-A and IFT-B. In contrast to the IFT-B complex, all components of IFT-A have recently been linked to human ciliopathies when defective. We therefore hypothesised that mutations in additional IFT-B encoding genes can be found in patients with multisystemic ciliopathies. METHODS We screened 1628 ...
We previously described a kinesin-dependent movement of particles in the flagella of Chlamydomonas reinhardtii called intraflagellar transport (IFT) (Kozminski, K.G., K.A. Johnson, P. Forscher, and J.L. Rosenbaum. 1993. Proc. Natl. Acad. Sci. USA. 90:5519-5523). When IFT is inhibited by inactivation of a kinesin, FLA10, in the temperature-sensitive mutant, fla10, existing flagella resorb and ne...
In the retina, aberrant opsin transport from cell bodies to outer segments leads to retinal degenerative diseases such as retinitis pigmentosa. Opsin transport is facilitated by the intraflagellar transport (IFT) system that mediates the bidirectional movement of proteins within cilia. In contrast to functions of the anterograde transport executed by IFT complex B (IFT-B), the precise functions...
The transport of flagellar precursors and removal of turnover products from the flagellar tip is mediated by intraflagellar transport (IFT) , which is essential for both flagellar assembly and maintenance . Large groups of IFT particles are moved from the flagellar base to the tip by kinesin-2, and smaller groups are returned to the base by cytoplasmic dynein 1b. The IFT particles are composed ...
BACKGROUND During the assembly and maintenance of cilia, precursor proteins need to be transported from the cell body into the organelle. Intraflagellar transport (IFT) is assumed to be the predominant protein transport pathway in cilia, but it remains largely unknown how ciliary proteins use IFT to reach their destination sites in the cilium and whether the amount of cargo transported by IFT i...
Cilia are assembled via intraflagellar transport (IFT). The IFT machinery is composed of motors and multisubunit particles, termed IFT-A and IFT-B, that carry cargo into the cilium. Knowledge of how the IFT subunits interact with their cargo is of critical importance for understanding how the unique ciliary domain is established. We previously reported a Chlamydomonas mutant, ift46-1, that fail...
Intraflagellar transport (IFT) is necessary for the construction of cilia and flagella. IFT proteins are concentrated at the base of the flagellum but little is known about the actual role of this pool of proteins. Here, IFT was investigated in Trypanosoma brucei, an attractive model for flagellum studies, using GFP fusions with IFT52 or the IFT dynein heavy chain DHC2.1. Tracking analysis by a...
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