نتایج جستجو برای: ifn β

تعداد نتایج: 211090  

2014
Bei Zheng Wei-Shan Chang

One pair of primers was designed according to Gallus and Meleagris gallopavo interferon β (IFN-β) sequences published in GenBank. The primers and RNA extraction from the spleen of Coturnix were used to amplify Coturnix IFN-β cDNA by real-time polymerase chain reaction (RT-PCR). The product was cloned into pEasy-T1 vector. Evaluating recombinant plasmid by PCR and restriction enzyme digestion. S...

Journal: :Brain, behavior, and immunity 2011
Cheryl M Sweeney Roisin Lonergan Sharee A Basdeo Katie Kinsella Lara S Dungan Sarah C Higgins Patrick J Kelly Lisa Costelloe Niall Tubridy Kingston H G Mills Jean M Fletcher

Interferon (IFN)-β is a commonly used therapy for relapsing remitting multiple sclerosis (RRMS). However its protective mechanism is still unclear and the failure of many patients to respond has not been explained. We have found that IFN-β suppressed IL-23 and IL-1β production and increased IL-10 production by human dendritic cells (DC) activated with the TLR2 and dectin-1 agonist zymosan. Furt...

Journal: :Journal of immunology 2014
Yazhong Tao Xin Zhang Manisha Chopra Ming-Jeong Kim Kinnari R Buch Dehan Kong Jianping Jin Yunan Tang Hongtu Zhu Valerie Jewells Silva Markovic-Plese

IFN-β has been used as a first-line therapy for relapsing-remitting multiple sclerosis (RRMS). Because only a few studies have addressed the role of endogenous IFN-β in the pathogenesis of the disease, our objective was to characterize its role in the transcriptional regulation of pathogenic Th17 cytokines in patients with RRMS. In vitro studies have demonstrated that IFN-β inhibits IL-17A, IL-...

Journal: :Journal of virology 2011
Adrish Sen Andrea J Pruijssers Terence S Dermody Adolfo García-Sastre Harry B Greenberg

In mouse embryonic fibroblasts (MEFs), the bovine rotavirus (UK strain) but not the simian rhesus rotavirus (RRV) robustly triggers beta interferon (IFN-β) secretion, resulting in an IFN-dependent restriction of replication. We now find that both rotavirus strains trigger antiviral transcriptional responses early during infection and that both transcriptional responses and IFN-β secretion are c...

2004
Gergana Hadjilambreva Eilhard Mix Arndt Rolfs Jana Müller Ulf Strauss

The immunomodulatory cytokine interferon-β (IFN-β) is used in the treatment of autoimmune diseases such as multiple sclerosis. However, the effect of IFN-β on neuronal functions is currently unknown. Intracellular recordings were conducted on somatosensory neurons of neocortical layers 2/3 and 5 exposed to IFN-β. The excitability of neurons was increased by IFN-β (10 – 10,000 U/ml) in two kinet...

2017
Yanrong Zhou Wei Wu Lilan Xie Dang Wang Qiyun Ke Zhenzhen Hou Xiaoli Wu Ying Fang Huanchun Chen Shaobo Xiao Liurong Fang

Transmissible gastroenteritis virus (TGEV), an enteropathogenic coronavirus (CoV) of porcine, causes lethal watery diarrhea and severe dehydration in piglets and leads to severe economic losses in the swine industry. Unlike most CoVs that antagonize type I interferon (IFN) production, previous studies showed that TGEV infection induces IFN-I production both in vivo and in vitro. However, the un...

2011
Adelle P. McFarland Ram Savan Sagie Wagage Augustina Addison Karthika Ramakrishnan Megan Karwan Tri Duong Howard A. Young

BACKGROUND There have been conflicting reports of the role of Type I interferons (IFN) in inflammatory bowel disease (IBD). Clinical trials have shown potent efficacy of systemic interferon-beta (IFN-β) in inducing remission of ulcerative colitis. Likewise, IFNAR1(-/-) mice display an increased sensitivity to dextran sulfate sodium (DSS)-induced colitis, suggesting Type I IFN play a protective ...

2017
Victoria A. McGuire Dalya Rosner Olga Ananieva Ewan A. Ross Suzanne E. Elcombe Shaista Naqvi Mirjam M. W. van den Bosch Claire E. Monk Tamara Ruiz-Zorrilla Diez Andrew R. Clark J. Simon C. Arthur

Autocrine or paracrine signaling by beta interferon (IFN-β) is essential for many of the responses of macrophages to pathogen-associated molecular patterns. This feedback loop contributes to pathological responses to infectious agents and is therefore tightly regulated. We demonstrate here that macrophage expression of IFN-β is negatively regulated by mitogen- and stress-activated kinases 1 and...

Journal: :RMŽ. Medicinskoe obozrenie 2022

Papillomaviruses are a group of DNA viruses belonging to the Papillomavirida family. These provoke pathological conditions manifesting with inflammation, exophytic masses, carcinogenesis, reproductive and perinatal disorders. Immune status is an essential factor de-termining severity duration inflammatory diseases, course latent viral infections, including papillomavirus infection (PVI). The hu...

Journal: :Science translational medicine 2015
Christopher J A Duncan Siti M B Mohamad Dan F Young Andrew J Skelton T Ronan Leahy Diane C Munday Karina M Butler Sofia Morfopoulou Julianne R Brown Mike Hubank Jeff Connell Patrick J Gavin Cathy McMahon Eugene Dempsey Niamh E Lynch Thomas S Jacques Manoj Valappil Andrew J Cant Judith Breuer Karin R Engelhardt Richard E Randall Sophie Hambleton

Type I interferon (IFN-α/β) is a fundamental antiviral defense mechanism. Mouse models have been pivotal to understanding the role of IFN-α/β in immunity, although validation of these findings in humans has been limited. We investigated a previously healthy child with fatal encephalitis after inoculation of the live attenuated measles, mumps, and rubella (MMR) vaccine. By targeted resequencing,...

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