The deployment of a software product requires considerable amount of time and effort. In order to increase the productivity of the software products, reusability strategies were proposed in the literature. However effective reuse is still a challenging issue. This paper presents a framework studio for effective components reusability which provides the selection of components from framework stu...

Background: The British Precursor Protein (BRI2) influences Amyloid Precursor Protein metabolism. Results: BRI2 lowers β-amyloid peptide levels by increasing levels of secreted insulin degrading enzyme (IDE) in both cells and mice. Conclusion: BRI2 as a receptor protein regulates IDE levels and in turn promotes βamyloid degradation. Significance: Targeting the regulation of IDE may lead to new ...

Selenium is open source software tool for automation testing .In this paper Firstly, we made analysis of selenium IDE with selenium Web Driver and Secondly, how we can enhance the Selenium IDE with using Web Driver and compatible with others browser. Now days the Web applications being developed to be compatible with all browsers but in Selenium IDE tool is limited to Firefox browser only and S...

Cloud computing is one of the latest computing paradigms and many companies are turning towards making it an integral component of their computing strategy. Cloud computing provides a way of taking applications online and all these applications and their associated data can be accessed with just an Internet connection and a web browser. Like many other softwares and applications, an Integrated ...

We have recently described the purification and characterization of an insulin-degrading enzyme (IDE) from Drosophila melanogaster that can cleave porcine insulin, is highly conserved through evolution and is developmentally regulated. We now report that the IDE is, in fact, an insulin EGF-binding protein (dp100) that we had isolated previously from Drosophila using an antihuman EGF receptor an...

Insulin-degrading enzyme (IDE) is an interesting pharmacological target for Alzheimer's disease (AD), since it hydrolyzes beta-amyloid, producing non-neurotoxic fragments. It has also been shown that the somatostatin level reduction is a pathological feature of AD and that it regulates the neprilysin activity toward beta-amyloid. In this work, we report for the first time that IDE is able to hy...

Denne artikel tager udgangspunkt i, at løsning af klima- og CO2-udledningskrisen kræver oversættelse samskabelse nye socio-tekniske løsninger i offentlig-private inno-vationsnetværk- grupper. Den redegør for ide-praksis-oversættelsesmodellens forståelse sådanne samskabelses-, design- oversættelsesprocesser for, hvad de ledelsesmæssige konsekvenser den er forbindelse. Endelig diskuteres, hvordan...

This paper presents a robust hybrid improved dolphin echolocation and ant colony optimization algorithm (IDEACO) for optimization of truss structures with discrete sizing variables. The dolphin echolocation (DE) is inspired by the navigation and hunting behavior of dolphins. An improved version of dolphin echolocation (IDE), as the main engine, is proposed and uses the positive attributes of an...

Regarding the development of distribution systems in the recent decades, fuel consumption of trucks has increased noticeably, which has a huge impact on greenhouse gas emissions. For this reason, the reduction of fuel consumption has been one of the most important research areas in the last decades. The aim of this paper is to propose a robust mathematical model for a variant of a vehicle routi...