Data on the ability of Delta 9-tetrahydrocannabinol (THC) to modify reward processes in experimental animals are inconsistent. This study examined the effects of Delta 9-THC on brain reward function using the rate-frequency curve shift paradigm of intracranial self-stimulation (ICSS) and the conditioned place preference (CPP) paradigm. In ICSS tests, rats were implanted with electrodes into the...

Context. Integrated control systems (ICSs) are heterogeneous systems where software and hardware components are integrated to control and monitor physical devices and processes. A family of ICSs share the same software code base, which is configured differently for each product to form a unique installation. Due to the complexity of ICSs and inadequate automation support, product configuration ...

Industrial systems present security risk factors related to their cyber vulnerabilities. These spread out over the world, continue be targets of attacks. While industrial share common vulnerabilities with Information Technology (IT) systems, they tend have more constraints due interaction between and physical systems. Intrusion detection give visibility system are considered one solutions detec...

In terms of cyber security metrics, ICSs tend to have unique features: in many cases, these systems are older technologies that were designed for functionality rather than security. They are also extremely diverse systems that have different requirements and objectives. Therefore, metrics for ICSs must be tailored to a diverse group of systems with many features and perform many different funct...

A growing body of evidence implicates endogenous cannabinoids as modulators of the mesolimbic dopamine system and motivated behavior. Paradoxically, the reinforcing effects of Δ(9)-tetrahydrocannabinol (THC), the primary psychoactive constituent of cannabis, have been difficult to detect in preclinical rodent models. In this study, we investigated the impact of THC and inhibitors of the endocan...

Pharmacological manipulation of the type 5 metabotropic glutamate (mGlu5) receptor alters various addiction related behaviors such as drug self-administration and the extinction and reinstatement of drug-seeking behavior. However, the effects of pharmacological modulation of mGlu5 receptors on brain reward function have not been widely investigated. We examined the effects of acute administrati...

In this paper, we have examined abrupt changes in volatility of TEPIX index in Tehran stock exchange during August 23, 2010 to June 12, 2014. Applying the iterated cumulative sum of squares (ICSS) algorithm proposed by Inclan and Tiao (1994) and the modified version of this algorithm consisting Kappa 1 and Kappa 2 test statistics developed by Sansó et al. (2004), we have specified that the dete...

This study estimates the effects of dual long memory property and structural breaks on persistence level six major cryptocurrency markets. We apply Bai Perron break test, Inclán Tiao’s iterated cumulative sum squares (ICSS) algorithm, fractionally integrated generalized autoregressive conditional heteroscedasticity (FIGARCH) model, with different distributions. The results show that characteriz...