نتایج جستجو برای: ici182780

تعداد نتایج: 52  

2016
Debrabata Chanda Jesus Prieto-Lloret Arjun Singh Hina Iqbal Pankaj Yadav Vladimir Snetkov Philip I Aaronson

BACKGROUND AND PURPOSE Glabridin is a major flavonoid in Glycyrrhiza glabra (licorice) root, a traditional Asian medicine. Glabridin is reported to have anti-atherogenic, anti-inflammatory and anti-nephritic properties; however its effects on vascular tone remain unexplored. EXPERIMENTAL APPROACH We examined the effect of glabridin on rat main mesenteric artery using isometric myography and a...

2010
Maria Laura Polo Maria Victoria Arnoni Marina Riggio Victoria Wargon Claudia Lanari Virginia Novaro

BACKGROUND A significant proportion of breast cancer patients face failure of endocrine therapy due to the acquisition of endocrine resistance. We have explored mechanisms involved in such disease progression by using a mouse breast cancer model that is induced by medroxyprogesterone acetate (MPA). These tumors transit through different stages of hormone sensitivity. However, when cells from tu...

Journal: :The Journal of pharmacology and experimental therapeutics 2008
Kyle A Rasbach Rick G Schnellmann

Mitochondrial damage is often both the cause and outcome of cell injury resulting from a variety of toxic insults, hypoxia, or trauma. Increasing mitochondrial biogenesis after renal proximal tubular cell (RPTC) injury accelerated the recovery of mitochondrial and cellular functions (Biochem Biophys Res Commun 355:734-739, 2007). However, few pharmacological agents are known to increase mitocho...

Journal: :American journal of physiology. Heart and circulatory physiology 2009
Baojian Xue Daniel Badaue-Passos Fang Guo Celso E Gomez-Sanchez Meredith Hay Alan Kim Johnson

The present study tested the hypotheses that male and female rats respond differently to subcutaneous infusions of aldosterone (Aldo; 1.8 microg.kg(-1).h(-1), 1% NaCl to drink; 28 days) and that central estrogen plays a protective role against the development of hypertension. In rats with blood pressure (BP) and heart rate (HR) measured by Data Sciences International telemetry, chronic Aldo/NaC...

1999
M. Kandouz A. Lombet J-Y. Perrot D. Jacob S. Carvajal A. Kazem W. Rostene A. Therwath A. Gompel

The promoting action of E2 in breast cancer cells has been, until now, mainly linked to its action on proli®eration. Because of the importance of an increase in apoptosis in breast cancer prevention, we have studied the possible e€ects of various antiestrogens, progestins and an androgen on its occurrence in three hormone-dependent breast cancer cell lines. The antiestrogens were, a triphenylet...

Journal: :Hypertension 2002
Federica Barchiesi Edwin K Jackson Delbert G Gillespie Lefteris C Zacharia Juergen Fingerle Raghvendra K Dubey

Estrogen receptors (ERs) are considered to mediate the ability of 17beta-estradiol (estradiol) to reduce injury-induced proliferation of vascular smooth muscle cells (VSMCs), leading to vascular lesions. However, the finding that estradiol attenuates formation of vascular lesions in response to vascular injury in knockout mice that lack either ER-alpha or ER-beta challenges this concept. Our hy...

Journal: :Endocrinology 2012
Jee Y Lee Soo Y Choi Tae H Oh Tae Y Yune

A delayed oligodendrocyte cell death after spinal cord injury (SCI) contributes to chronic demyelination of spared axons, leading to a permanent neurological deficit. Therefore, therapeutic approaches to prevent oligodendrocyte cell death after SCI should be considered. Estrogens are well known to have a broad neuroprotective effect, but the protective effect of estrogens on oligodendrocytes af...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2009
Zhiguo Chu Josefa Andrade Margaret A Shupnik Suzanne M Moenter

Gonadotropin-releasing hormone (GnRH) neurons are critical to controlling fertility. In vivo, estradiol can inhibit or stimulate GnRH release depending on concentration and physiological state. We examined rapid, nongenomic effects of estradiol. Whole-cell recordings were made of GnRH neurons in brain slices from ovariectomized mice with ionotropic GABA and glutamate receptors blocked. Estradio...

Journal: :The Journal of endocrinology 2005
Liat Abovich Gilad Tali Bresler Julia Gnainsky Patricia Smirnoff Betty Schwartz

We previously demonstrated that 17beta-estradiol (E2) regulates the transcription and expression of the vitamin D receptor (VDR) in rat colonocytes and duodenocytes in vivo. The aim of the present study was to assess whether the extracellular signal-regulated kinase (ERK) induced by E2 is involved in regulating VDR expression. We compared E2-associated signaling activity in HT29 colon cancer ce...

Journal: :Reproductive biology and endocrinology : RB&E 2003
Denis Stygar Natalia Muravitskaya Britt Eriksson Håkan Eriksson Lena Sahlin

BACKGROUND Selective estrogen receptor modulators (SERMs) have been developed in order to create means to control estrogenic effects on different tissues. A major drawback in treatment of estrogen receptor (ER) positive breast cancer with the antagonist tamoxifen (TAM) is its agonistic effect in the endometrium. Raloxifene (RAL) is the next generation of SERMs where the agonistic effect on the ...

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