نتایج جستجو برای: icb
تعداد نتایج: 357 فیلتر نتایج به سال:
BACKGROUND An elevated Neutrophil-to-lymphocyte ratio (NLR) is associated with worse outcomes in several malignancies. However, its role with contemporary immune checkpoint blockade (ICB) is unknown. We investigated the utility of NLR in metastatic renal cell carcinoma (mRCC) patients treated with PD-1/PD-L1 ICB. METHODS We examined NLR at baseline and 6 (±2) weeks later in 142 patients treat...
The suppression of spontaneous motor impulses is an essential facet of cognitive control that is linked to frontal-BG circuitry. BG dysfunction caused by Parkinson disease (PD) disrupts the proficiency of action suppression, but how pharmacotherapy for PD impacts impulsive motor control is poorly understood. Dopamine agonists improve motor symptoms of PD but can also provoke impulsive-compulsiv...
Malignancies of the central nervous system (CNS), particularly glioblastoma and brain metastases from a variety of disease sites, are difficult to treat despite advances in multimodality approaches consisting of surgery, chemotherapy, and radiation therapy (RT). Recent successes of immunotherapeutic strategies including immune checkpoint blockade (ICB) via anti-PD-1 and anti-CTLA-4 antibodies a...
Abstract Introduction: Immune checkpoint blockade (ICB) therapy has been revolutionary in its ability to treat advanced malignancies. Yet many patients receiving ICB develop related adverse events (IRAEs), a leading cause for discontinue treatment. Analyzing who IRAEs can help advance our knowledge of the molecular drivers these poorly understood off target toxicities. Methods: Our recent study...
S U M M A R Y Precise determination of the topography of a major internal boundary of the Earth is difficult because of the trade-off with the unknown velocity structure above it. However, the discoveries of the inner core (IC) rotation and high-quality teleseismic waveform doublets make the precise mapping of the topography of the inner core boundary (ICB) possible. Here we examine IC refracte...
s of the XXX ESAO COGRESS „Hi tech & Medicine”. Aachen – Germany, 3-6 September 2003. The Journal of Artificial Organs 2003; 26: 668. 34. Nawrat Z. Perspectives of computer and robot assisted surgery for heart assist pump implantation. Planning for robotically assisted surgery. Lecture notes of the ICB Seminars. Assessment and mechanical support of heart and lungs. Darowski M, Ferrari G (ed.). ...
Cristallographie, Résonance Magnétique et Université de Lorraine, BP 70239, Bd des A France. E-mail: emmanuel.aubert@univ-lorr Laboratoire SRSMC, UMR CNRS 7565, U Aiguillettes, Vandoeuvre-les-Nancy 54506, F Istituto di Chimica Biomolecolare ICB CNR Crucca 3, Regione Baldinca, I-07100 Li Pun Istituto di Chimica Biomolecolare ICB CNR (Na), Italy Institut Jean Lamour, CNRS-Université de Vandœuvre-...
به منظور بررسی و تایید مقاومت لاین های پیشرفته جو دیم نسبت به بیماری سفیدک پودری،44 لاین پیشرفته و کاندید برای معرفی در سال های زراعی 1382-1380 در دو منطقه کرج و گرگان برای دو سال در قالب طرح بلوک های کامل تصادفی با سه تکرار کاشته و در مرحله گیاه کامل بر اساس روش ســاری و پرســکات ارزیابی شدند. در آزمایش گلخانه ای در مرحله گیاهچه ای، ابتدا جدایه های عامل بیماری از مناطق مذکور جمع آوری و به گلخا...
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