DNA amplification at 20qi3.2 is common in breast cancer, correlates with poor prognosis, and may reflect location of an important oncogene. Recently, other regions along 20q were also found to undergo amplifica tion. Here, amplification levels and patterns of co-amplification were analyzed by interphase fluorescencein situ hybridization at i4 locialong 20q in i46 uncultured breast carcinomas an...

Following the hypothesis that chronic ischemia is the main cause of functional deficiency in glaucoma, a double blind clinical experiment was carried out to study the effect of hyperbaric oxygenation in 51 glaucoma subjects, of which 31 were in the experimental group and 20 in the control group. In the experimental group there was a significant improvement of visual fields (p < 0.05), whereas t...

We have used a combined photochemicalcondensation model to study hydrocarbon ices produced from CH4 photolysis in the stratosphere of Neptune. We predict a total stratospheric haze production rate of 4.2 X 10-15 grams cm -2 s -1 (75% ethane, 25% acetylene, trace diacetylene). The total production rate is insensitive to within a factor of two to order of magnitude changes in the eddy diffusion c...

Assembly of fibronectin fibrils occurs at the surface of substrate-attached cells and is mediated by the first to the fifth type I modules in the N-terminal 70 kDa portion of the molecule. The first type III module (III1) of fibronectin, not present in the 70 kDa portion, contains a conformation-dependent binding site for the 70 kDa N-terminal region of fibronectin, suggesting that the III1 mod...

In plant mitochondria, gene expression of translatable mRNAs is a complex process with two critical steps, RNA editing and splicing. We studied the role of RNA editing on non-coding regions of the mat-r-nad1e-nad5c transcript from wheat mitochondria. This RNA contains two trans-introns, 3'-nad1-I4 and 3'-nad5-I2, involved in different trans-splicing events, ensuring the association of nad1d-nad...

Postoperative cognitive dysfunction (POCD) is a decline in cognitive performance after a surgery with anaesthesia. The exact reasons of surgery and/or anaesthesia resulting in POCD are unclear. The aim of this study is to investigate the effects of different concentration and duration time of isoflurane anaesthesia on cognitive performance and cellular mechanisms involved in learning and memory...

We analyse the spectrum of non-BPS branes in the type I theory on the orbifold T /I4. We present a detailed analysis of the action of the worldsheet parity Ω on the different D-brane boundary state sectors of type IIB on T /I4, using the covariant formulation. Using these results we derive the spectrum of branes in the type I orbifold. We find ZZ2and ZZcharged non-BPS branes. A study of the sta...