نتایج جستجو برای: i3
تعداد نتایج: 2095 فیلتر نتایج به سال:
Human discs large (hDlg) protein binds to protein 4.1R via a motif encoded by an alternatively spliced exon located between the SH3 and the C-terminal guanylate kinase-like domains. To evaluate the functional significance of protein 4.1R binding for subcellular localization of hDlg in vivo, we expressed full-length recombinant constructs of two naturally occurring isoforms of hDlg termed hDlg-I...
Numerous data showed that 5-hydroxytryptamine-1A (5-HT1A) receptors couple to Galpha(o)/alpha(i) proteins for signal transduction. However, the alpha subunit isoforms really involved in 5-HT1A receptor coupling in brain remain to be identified. Moreover, regional differences in the functional characteristics of brain 5-HT1A receptors have been evidenced repeatedly. Because such differences coul...
In this article, we propose a framework to accelerate the ubiquitous capitalization of Internet as a vehicle to merchandise goods and services. The motivation for proposing this framework derives from the fact that many consumers and small-to-medium-sized companies are still hesitant to use Internet to shop, trade and disclose sensitive information such as credit card numbers. While IT security...
Metal-free carbon-based electrocatalysts for dye-sensitized solar cells (DSSCs) are sufficiently active in Co(II)/Co(III) electrolytes but are not satisfactory in the most commonly used iodide/triiodide (I(-)/I3 (-)) electrolytes. Thus, developing active and stable metal-free electrocatalysts in both electrolytes is one of the most important issues in DSSC research. We report the synthesis of e...
BACKGROUND Two pertussis toxin sensitive G(i) proteins, G(i2) and G(i3), are expressed in cardiomyocytes and upregulated in heart failure. It has been proposed that the highly homologous G(i) isoforms are functionally distinct. To test for isoform-specific functions of G(i) proteins, we examined their role in the regulation of cardiac L-type voltage-dependent calcium channels (L-VDCC). METHOD...
Platelet-activating factor (1-O-alkyl-2-acetyl-sn-glycerolphosphocholine; PAF) induces leukocyte accumulation and activation at sites of inflammation via the activation of a specific cell surface receptor (PAFR). PAFR couples to both pertussis toxin-sensitive and pertussis toxin-insensitive G proteins to activate leukocytes. To define the role(s) of G(i) and G(q) in PAF-induced leukocyte respon...
We prove that the existence of a slightly massive gravitino or gaugino in a class of Gaussian string compactifications, implies the existence of an entire tower of such states below Mplanck, signaling the approach to a limit of decompactification. Submitted to Physics Letters I3 *Work supported by the Department of Energy, contract DE-AC03-76SF00515. TPermanent address: C.P.T.,, Ecole Polytechn...
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