BACKGROUND The purpose of this study was to investigate expression of recepteur d'origine nantais (RON) in human hypopharyngeal squamous cell carcinoma (SCC) and to determine whether RON affects tumor cell behavior in hypopharyngeal SCC cell line and if this would serve as a target for molecular therapy in a preclinical model. METHODS Reverse transcriptase-polymerase chain reaction, immunohis...

Dear Editor, Patients with hypopharyngeal carcinoma often present with locally advanced disease. Treatment options are usually multimodality and involve surgery, radiotherapy (RT) and chemotherapy. Definitive RT with or without chemotherapy present a functional organ preservation strategy in selected patients or in patients with extensive inoperable local disease. Whereas upfront surgery follow...

OBJECTIVES/HYPOTHESIS The objective was to characterize incidence, treatment, and survival for hypopharyngeal cancer in the United States between 1988 and 2010, and to analyze associations between changes in treatment modality and survival. STUDY DESIGN Retrospective cohort study. METHODS A total of 3,958 adult patients with hypopharyngeal cancer were identified in the Surveillance, Epidemi...

The transcription factor TWIST is an important factor in regulating epithelial-mesenchymal transition (EMT) and tumor metastasis. To explore the functions of TWIST in hypopharyngeal cancer, we investigated if overexpression of TWIST has an effect on FaDu cell morphology, and if alteration of TWIST has an effect on E-cadherin, N-cadherin, c-fos, MM...

Introduction: Advanced laryngeal and hypopharyngeal cancers are aggressive tumors with a poor prognosis. Multiple lymph node metastases often occur in the neck as well as in the upper mediastinum and thus upper mediastinal dissection is crucial to improving the cure rate. However, excessive mediastinal dissection can increase postoperative morbidity and mortality making it important to employ t...

Introduction: Computed tomography (CT) imaging is the choice of investigation for evaluation of extent of tumor under the mucosa, locally and regionally. This study was undertaken to assess the accuracy of preoperative CT imaging in the staging of carcinoma of the larynx and hypopharynx.   Materials and Methods: In this retrospective study, all cases who were clinically (c) staged T3–T4 and w...

PURPOSE The aim of this study was to evaluate treatment results in our hypopharyngeal cancer patients. PATIENTS AND METHODS A total of three hundred and ninety five hypopharyngeal cancer patients received radical treatment at our hospital; 96% were male. The majority were habitual smokers (88%), alcohol drinkers (73%) and/or betel quid chewers (51%). All patients received a CT scan or MRI for...