BACKGROUND Both severe stenosis and completed occlusion in internal carotid artery or its distal branches have been considered the main reasons of cerebral hypoperfusion, which contributes to the washout disturbances of embolism in low perfusion territories distal to stenosis. An aggravated hypoperfusion state in certain brain region may induce ischemic stroke and further cognitive decline. How...

Background: Physical examination remains the cornerstone in assessment of acute heart failure. There is a lack adequately powered studies assessing combined impact both systolic blood pressure (SBP) and hypoperfusion on short-term mortality. Methods: Patients with failure from 41 Spanish emergency departments were recruited consecutively 3 time periods between 2011 2016. Logistic regression mod...

Reperfusion into focal ischemia was studied in 25 cats after middle cerebral artery (mca) occlusion of 15 min to 2 hours duration. Changes in cerebral blood flow (CBF) were followed with the hydrogen clearance method in the center and periphery of the ischemic lesion expected. Postischemic hyperperfusion was found often after 15 and 30 min ischemia and regularly after 60 min mca occlusion. It w...

Traditionally hypoperfusion and embolism are considered separate important causes of stroke in patients with arterial occlusive disease. However, although hypoperfusion and embolism differ in mechanisms and location, they generally coincide in severe obstructive lesions and cause washout disturbances of embolism in low perfusion territories distal to stenosis. Unless the collateral blood supply...

UNLABELLED Brain SPECT imaging (BSI) with statistical parametric mapping (SPM) offers a clear and accurate vision of perfusion changes. OBJECTIVE To study brain perfusion abnormalities in adolescents' dependent of multiple drugs. METHOD Sixteen male patients (15.1 + or - 2.1 years) were submitted to (99m)Tc-HMPAO BSI with SPM. RESULTS Cortical hypoperfusion occurred in 7/16 patients (44%)...

In the current investigation, the status of the septo-hippocampal cholinergic pathway and hippocampal mitogen-activated protein kinase (MAPK) signaling was examined in male Wistar rats with chronic cerebral hypoperfusion, which showed cognitive deficits based on assessment on a version of the Morris water maze. Chronic cerebral hypoperfusion was induced by bilateral common artery occlusion and ...

Results We studied, 112 consecutive patients 108 of them had performed. coronary angiography, 66 males(61%), Mean age 66±10 years 5 (4.6%) without significant coronary lesions (PPV: 95%). Patients with hypoperfusion > 50% in any segment (79 patients 73%) had a number significantly higher of affected vessels (2±0,8 vs 1,6± 0,9 p=0.04), greater number of segments with systolic dysfunction induced...

This series case report aimed to elucidate the underlying pathology and outcomes of lateral medullary infarction (LMI) using perfusion weighted imaging (PWI). Four patients were diagnosed with LMI based on high-field diffusion-weighted magnetic resonance imaging (MRI-DWI) and PWI. The national institutes of health stroke scale (NIHSS) scores were recorded on days 1, 7, and 30, and the Barthel i...

INTRODUCTION It is hypothesized that cerebral hypoperfusion promotes the development of Alzheimer pathology. We therefore studied whether longstanding cerebral hypoperfusion is associated with Alzheimer pathology in nondemented humans. METHODS Cerebral blood flow and amyloid β (18F-Flutemetamol) positron emission tomography retention were assessed in eleven patients with unilateral occlusion ...

We have hypothesized that most cases of aphasia or hemispatial neglect due to acute, subcortical infarct can be accounted for by concurrent cortical hypoperfusion. To test this hypothesis, we demonstrate: (i) that pure subcortical infarctions are associated with cortical hypoperfusion in subjects with aphasia/neglect; (ii) that reversal of cortical hypoperfusion is associated with resolution of...