ramelteon (Rozerem, Takeda). In researching this topic, we conducted a PubMed literature search using the terms hypnotics and sedatives; insomnia; sleep disorders; pulmonary disease, chronic obstructive; and ramelteon. Our search included all studies conducted between January 1996 and September 2008. We then supplemented the clinical literature according to an analysis of the references collect...

INTRODUCTION There are many common drugs which have significant sedative-hypnotic properties. Alcohol and barbiturates have been discussed separately in this appendix, and their many pharmacological similarities were indicated. Barbiturates are often considered the prototype of sedative-hypnotic drugs; pharmacologically related compounds are frequently identified or discussed in terms of their ...

AIMS Entering entrepreneurship (i.e. becoming an entrepreneur) is known to be a demanding activity with increased workload, financial uncertainty and increased levels of stress. However, there are no systematic studies on how entering entrepreneurship affects the people involved. METHODS The authors investigated prescriptions of psychotropics for 6,221 first-time entrepreneurs from 2001-2004 ...

BACKGROUND While antidepressant-induced suicidality is a concern in younger age groups, there is mounting evidence that these drugs may reduce suicidality in the elderly. Regarding a possible association between other types of psychoactive drugs and suicide, results are inconclusive. Sedatives and hypnotics are widely prescribed to elderly persons with symptoms of depression, anxiety, and sleep...

The reviewer is a long-time critic of hypnotics who has recently proposed U.S. Food and Drug Administration action to mandate additional Phase IV safety trials or else to restrict hypnotic indications. See Sleep Medicine, 2016, http://dx.doi.org/10.1016/j.sleep.2015.12.011 , the FDA documents at https://www.regulations.gov/#!docketDetail;D=FDA-2015-P-3959 and www.DarkSideOfSleepingPills.com . R...

OBJECTIVES Nonmedical prescription opiate use (NPOU) and nonmedical prescription sedative use (NPSU) are serious public health concerns. The objectives of this study were to determine the prevalence and emergency department (ED) visit characteristics and other correlates associated with past-year NPOU and NPSU among adolescents and young adults using the ED. METHODS Participants aged 14 to 20...

OBJECTIVE Lumbar puncture (LP) is usually associated with anxiety and apprehension in children and their parents. This study was performed for controlling children's anxiety before and during LP and increasing the success of LP due to relaxation of the child following the use of sedative drugs and to compare the efficacy and side effects of oral midazolam and oral chloral hydrate. METHOD This...