Original Article 1. Introduction The incidence of chronic hypervitaminosis A is becoming more frequent problem worldwide due to the to the increasing use of vitamin A supplements in children of developing countries where vitamin A deficiency is commonplace, treatment of skin disorders such as acne and the increased number of people taking excessive doses of vitamin A for supposed beneficial hea...

in this investigation the effects of excess vitamin a administration during the early embryonic period were studied. intramuscular injection of a single dose of 15000,20000 or 25000 iu/kg vitamin a to pregnant balb/c strain mice on either day 7,8,9 or 10 of gestation (vaginal plug= day 0 of gestation) produced major malformations in the central nervous system (cns) including exencephaly, hydroc...

THE object of this paper is to record a continuation of experiments in which the existence is demonstrated of a "balance" between the vitamin B complex on the one hand and vitamins A and D of cod-liver oil on the other. Only two previous communications bearing directly on this subject have appeared in the literature, so far as we are aware. In the first place, Hopkins [1923] mentioned that he h...

Young male Sprague-Dawley rats were fed oral supplements of vitamin A; either a subtoxic dose of 5000 i.u./day for 16 weeks (10 animals), or a toxic dose of 15,OOOi.u./day for 16 days (5 animals). High-dose animals exhibited signs of acute toxicity; low-dose animals demonstrated only less weight gain than controls. Vitamin A sera and liver levels evidenced intoxication. Light and electron micro...

INTRODUCTION Vitamin D is increasingly recognized to have several beneficial effects. Vitamin D deficiency is widely prevalent. Physicians often treat patients with high doses of vitamin D for various ailments without any monitoring for adverse effects and the prescribed doses often far exceed requirements resulting in toxicity. We present here a classic case of iatrogenic hypervitaminosis D, w...