Hypericin and pseudohypericin were found in 27 of the 36 evaluated species from Hypericum L., belonging to 17 sections of the genus. Pseudohypericin is reported by us in 15 taxa for the first time. Most of the species contained both components and the amount of pseudohypericin usually exceeded that of hypericin. In H. hirsutum and H. empetrifolium only hypericin was found, whereas H. formosissi...

Therapeutic uses of Hypericum extracts have been demonstrated as safe and effective in treating mild to moderate depression in numerous clinical trials. To date, however, no definitive statements on their mode of action can be made, and little information on their electrophysiological effects is available. The present communication summarises the results of our efforts directed towards clarifyi...

Valeriana Officinalis L. e a Hypericum Cavernicola B. SM., são espécies que apresentam uso medicinal para dores de cabeça anti-inflamatório. Plantas medicinais têm sido propagadas por métodos micropropagação é propagação clonal um genótipo selecionado in vitro. O objetivo do trabalho foi avaliar os efeitos das diferentes concentrações meio cultura MS BAP na Cavernicola. realizado no Laboratório...

BACKGROUND Extracts of Hypericum perforatum (St. John's wort) have been traditionally recommended for a wide range of medical conditions, in particular mild-to-moderate depression. The present study was designed to investigate the effect of Hypericum perforatum treatment in a mouse model of anxiety/depressive-like behavior, induced by chronic corticosterone administration. METHODS CD1 mice we...

Depression is a common condition in the community with a significant impact on affected individuals, their relatives and society. Many patients with depression do not seek treatment and are often concerned about the possible adverse effects of antidepressant drugs. Extract of Hypericum perforatum (St. John's wort) has long been recognized as a treatment for depression. Several published trials ...

Hypericin is a pigment present in the widely distributed medicinal plant Hypericum perforatum L. (Hypericaceae). In our research, hypericin was found to be an inhibitor of NADPH/Fe 2+ induced microsomal lipid peroxidation and NADPH-dependent lucigenin chemiluminescence emission in vitro. Hypericin also inhibited the microsomal CYP1Adependent 7-ethoxyresorufin O-deethylase (EROD) which participa...

The experiment was conducted to proof the new natural plant extracts (Fagopyrum Mill. (buckwheat), Crataegus ex L., (hawthorn), Hypericum L. (St -John's -wort's) and Helichrysum arenarium) and selected flavonoids as reference substances for the in vitro. The probing was performed as considering four different parameters: the antioxidant activity, the antiradical activity – DPPH test, the DPH te...

Objective: Hypericum perforatum has demonstrated antidepressant efficacy when compared to placebo, but comparisons with other antidepressants remain controversial. We assessed the efficacy and safety of Hypericum perforatum in comparison with fluoxetine, in a 8-week double-blind trial in patients with mild to moderate depression. Method: Seventy-two outpatients were randomly assigned to receive...