Abnormalities of the uterine cavity can be a contributing cause of subfertility, and assessment of this factor has been suggested as a routine investigation in the evaluation of subfertile women. Hysterosalpingography has been used as the most common procedure in the investigation of infertility cause. Saline infusion sonohysterography can show uterine cavity abnormalities, which is highly sens...

About 1/3rd of all women diagnosed with subfertility have a tubo-peritoneal factor contri‐ buting to their condition. Most of these alterations in tubo-ovarian function come from post-inflammatory damage inflicted after a pelvic or sexually transmitted infection. Sal‐ pingitis occurs in an estimated 15% of reproductive-age women, and 2.5% of all women become infertile as a result of salpingitis...

During the days August 22-24, 2013 has been held in Harbin (China) an International Consensus Conference aimed to improve the quality and the reporting of the randomized controlled trials (RCTs) in infertility and subfertility field. I, as Italian scientist with experience in clinical infertility trials, was invited to have a speech on the Italian experience in RCTs, with particular regard for ...

BACKGROUND The aim of the study was to test whether the use of sonography contrast could enhance the chance of spontaneous clinical pregnancy in women undergoing subfertility investigation. METHODS Couples with at least 1 year of infertility who were scheduled for a consultation including a hysterosalpingo contrast sonography (HyCoSy) were invited to participate in the study. We compared flus...

The global health problems of infertility and sperm dysfunction In a world in which population growth and its subsequent control seem to be critical problems, it is counterintuitive to think that one in six couples are subfertile (still trying for a child after over 1 year of unprotected intercourse). In fact, approximately 80 million couples throughout the world are subfertile [1]. What is per...

The appropriateness of many investigations for subfertility will continue to be of debate for some time yet. Of most benefit to the concerned couple would be a process that is diagnostically accurate, expeditious and reliable. It should be performed with a minimum of invasion and provide both patient and clinician with useful prognostic information regarding possible future treatment. This arti...

Abstract Embryonic aneuploidy from mis-segregation of chromosomes during meiosis causes pregnancy loss. Proper disjunction homologous requires the mismatch repair (MMR) genes MLH1 and MLH3 , essential in mice for fertility. Variants these can increase colorectal cancer risk, yet reproductive impacts are unclear. To determine if MLH1/3 single nucleotide polymorphisms (SNPs) human populations cou...