The relative risk of developing coronary artery disease (CAD) in Pakistani men is highest in early ages. Majority of those suffering from CAD belong to the lower middle socioeconomic stratum of the society. Mild hyperhomocysteinemia (concentration of plasma homocysteine between 15-25 micromol/l) is very commonly seen in Pakistani patients with acute myocardial infarction (AMI) as well as in nor...

Homocysteine is a sulfurated amino acid used for the synthesis of methionine. The last decade's researches proved that hyperhomocysteinemia is an independent risk factor for atherosclerotic vascular disease. The vascular injury induced by several mechanisms of hyperhomocysteinemia is the hallmark of homocysteine's atherogenic properties. Hyperhomocysteinemia is present in 85% of the patients wi...

Introduction-Chronic Kidney Disease is growing problem across all over world and India as well. Chronic kidney disease encompasses a spectrum of different pathophysiological processes associated with abnormal function progressive decline in glomerular filtration rate(GFR).The risk for cardiovascular (CVD) morbidity mortality remains high stages CKD, including patients hemodialysis. More CKD die...

Homocysteine is an amino acid produced when proteins are broken down. A high homocysteine level, also called hyperhomocysteinemia, can contribute to arterial damage and blood clots in your vessels. Hyperhomocysteinemia (Hhcy) occurs chronic kidney disease (CKD) patients because of impaired renal metabolism reduced excretion Chronic failure a condition involving decrease the kidneys' ability fil...

C entral retinal vein occlusion (CRVO) in the young is also known as papillophlebitis and is a rare presentation.1 Retinal vein occlusion has been known to be associated with many systemic conditions.1,2 Association of hyperhomocysteinemia with retinal vein occlusion was reported in the literature.2-4 There was controversy, however, over whether there was correlation between methylenetetrahydro...

Cardiovascular and peripheral vascular disease are the major cause of morbidity and mortality in general population today. Hyperhomocysteinemia, a new independent risk factor for atherosclerotic vascular disease, has been described in the last ten years. Moderate hyperhomocysteinemia occurs in 5-7% of general population, and is associated in the third and fourth deceny of life with premature co...

Hyperhomocysteinemia, highly prevalent in well-nourished patients with chronic renal failure and in uremia, causes toxic effects that can be envisioned in terms of cardiovascular risk increase. However, its effects on cellular metabolism and on gene expression, not to mention receptor regulation, only recently are being evaluated. For example, it has been shown that hypomethylation induced by h...

purpose: to evaluate total plasma homocysteine level during the acute phase of central retinal vein occlusion (crvo) compared with a matched healthy group in iranian population, and determine whether hyperhomocysteinemia is also a risk factor for crvo. methods: a study group contains 54 patients presenting with crvo in recent one month, acute phase of the decease, was compared for fasting total...

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Hyperhomocysteinemia is a known risk factor for cardiovascular diseases, but the underlying mechanisms of this pathology are complex. We aimed to evaluate the effect of hyperhomocysteinemia in vasorelaxations induced by alpha(1D)-adrenoceptor agonists. Vascular reactivity of rat carotid artery to the alpha-adrenoceptor agonist, phenylephrine, was enhanced in hyperhomocysteinemia. Mechanical rem...