نتایج جستجو برای: hypercortisolism
تعداد نتایج: 663 فیلتر نتایج به سال:
CONTEXT Increased bone fragility is a frequent complication of hypercortisolism due predominantly to suppression of bone formation. Sclerostin is an osteocyte-produced negative regulator of bone formation, which is up-regulated by glucocorticoids in mice. OBJECTIVE Our objective was to assess the effect of endogenous hypercortisolism on circulating sclerostin and bone turnover in humans. DE...
CONTEXT The hypothalamus-pituitary-thyroid axis in Cushing's syndrome may be altered. Previous reports have shown diminished serum TSH concentration and decreased response to TRH. OBJECTIVE We analyzed serum TSH profiles in relation to cortisol profiles in patients with hypercortisolism of pituitary (n=16) or primary-adrenal origin (n=11) and after remission by pituitary surgery (n=7) in orde...
OBJECTIVE To study the prevalence of primary thyroid disorders in patients who underwent endogenous hypercortisolism. DESIGN Retrospective evaluation of 59 patients with Cushing's syndrome (CS) who had, at least, a record of thyroid palpation by expert endocrinologists and basal measurements of TSH by second generation assays. When available, tri-iodothyronine and thyroxine serum levels, TRH-...
Abstract Introduction: Ectopic ACTH syndrome is rare but frequently a severe condition because of the intensity hypercortisolism. Patient management complex and demands both strategies: diagnosis treatment Cushing syndrome, specific neuroendocrine tumors. Therefore, should be performed ideally by experienced endocrinology teams in collaboration with surgeons, oncologists, nuclear medicine, spec...
Adrenal myelolipomas are rare adrenal tumors generally diagnosed incidentally. A 42-year-old female reported to us with complaints of left flank pain attributable to her left ureteric calculi. On evaluation, a large adrenal mass was diagnosed along with hypercortisolism. After adrenalectomy, the histopathology revealed adrenal myelolipoma along with osseous metaplasia not reported in English li...
Both stress-system activation and melancholic depression are characterized by fear, constricted affect, stereotyped thinking, and similar changes in autonomic and neuroendocrine function. Because norepinephrine (NE) and corticotropin-releasing hormone (CRH) can produce these physiological and behavioral changes, we measured the cerebrospinal fluid (CSF) levels each hour for 30 consecutive hours...
Hospital Physician April 2008 25 C ushing’s syndrome was first described by Harvey Cushing in 1910 in a woman with central obesity, abdominal striae, hirsutism, amenorrhea, hypertension, proximal muscle weakness, thinning hair, and purpura.1,2 Cushing’s syndrome is now known to be associated with hypercortisolism, either endogenous or exogenous in origin. Endogenous causes of Cushing’s syndrome...
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