The detection of immunological phenomena in pernicious anaemia (Schwartz, 1958; Taylor, 1959) introduced the concept of immunological assay of intrinsic factor. Several methods in which antibodies against intrinsic factor are used are now available (Jeffries and Sleisenger, 1965; Herbert, Gottlieb, Lau, and Wasserman, 1964; Abels, Bouma, Jansz, Woldring, Bakker, and Nieweg, 1963; Ardeman Chanar...

The (-)-hyoscyamine, atropine and scopolamine (hyoscine) are three valuable tropane alkaloids while scopolamine is the most important member of this group for the pharmaceutical industry due to its higher demand compared to hyoscyamine and atropine. Scopolamine is an anticholinergic reagent with several therapeutic applications. In the current study, the hairy roots culture of Daturametel was u...

black henbane (bh) or hyoscyamus niger, has been used as a medicine since last centuries and has been described in all traditional medicines. it applies as a herbal medicine, but may induce intoxication accidentally or intentionally. all part of bh including leaves, seeds and roots contain some alkaloids such as hyoscyamine, atropine, tropane and scopolamine. bh has pharmacological effects like...

[1] Ziegler J, Facchini PJ (2008) Alkaloid Biosynthesis: Metabolism and Trafficking. Annu Rev Plant Biol 59:735–769. doi: 10.1146/annurev.arplant.59.032607.092730 [2] Averesch NJH, Kayser O (2014) Assessing Heterologous Expression of Hyoscyamine 6β-Hydroxylase – A Feasibility Study. Procedia Chem 13:69–78. doi: http://dx.doi.org/10.1016/j.proche.2014.12.008 [3] Kim, HK, Choi YH, Verpoorte R, (2...

Background: Black henbane with the scientific name of Hyoscyamus niger which has a wide geographic distribution, is considered as one the most important species for tropane alkaloids extraction. Objective: In this research, morphological and tropane alkaloids variations were assessed within different population of H. niger in their natural habitats. Methods: Totally, 56 individuals were colle...

PATIENT Female, 70 FINAL DIAGNOSIS: SA block induced by pyridostigmine Symptoms: Asymptomatic Medication: Pyridostigmine Clinical Procedure: Pacemaker insertion Specialty: Electrophysiology. OBJECTIVE Unusual clinical course. BACKGROUND Myasthenia gravis requires a long-term treatment with a parasympathomimetic agent, which may result in bradycardia and asystole. Pharmacologic treatment wit...