نتایج جستجو برای: hymenocardia acida

تعداد نتایج: 210  

Journal: :Anesthesiology 2001
R A Nicholson J Zheng C R Ganellin B Verdon G Lees

BACKGROUND cis-9,10-Octadecenoamide (cOA) accumulates in cerebrospinal fluid during sleep deprivation and induces sleep in animals, but its cellular actions are poorly characterized. In earlier studies, like a variety of anesthetics, cOA modulated gamma-aminobutyric acidA receptors and inhibited transmitter release/burst firing in cultured neurones or synaptoneurosomes. METHODS Here, radiolig...

Journal: :The Journal of pharmacology and experimental therapeutics 1999
D A Finn J C Crabbe

Withdrawal seizure-prone (WSP) and withdrawal seizure-resistant (WSR) mice were selectively bred to have severe (WSP) or mild (WSR) handling-induced convulsions after chronic ethanol inhalation. The purpose of the present experiments was to determine whether seizure susceptibility differences between WSP and WSR mice during ethanol withdrawal were specific to agents acting at gamma-aminobutyric...

2012
A. A Raw

The wood micro cellular structural constituents of five lesser used wood species in Nigeria among which are Butyrospermum paradoxum, Albizia zygia, Lanea acida, Parkia felicoida and Isoberlina doka are determined. Fibre cells accounts for 54% of the total wood micro cellular constituents of B. paradoxum while vessel, axial and ray parenchyma cells make up the rest of the wood micro structural c...

Journal: :The Journal of pharmacology and experimental therapeutics 1999
M Y Wang I J Rampil J J Kendig

Ethanol is a general anesthetic agent as defined by abolition of movement in response to noxious stimulation. This anesthetic endpoint is due to spinal anesthetic actions. This study was designed to test the hypothesis that ethanol acts directly on motor neurons to inhibit excitatory synaptic transmission at glutamate receptors. Whole cell recordings were made in visually identified motor neuro...

1997
JANET L. FISHER JIE ZHANG ROBERT L. MACDONALD

The g-aminobutyric acidA (GABA) receptor in the mammalian central nervous system is composed of pentameric combinations of a1–6, b1–4, g1–3, d1, and/or e1 subunit subtypes. Although each of the different subunits influences the functional properties of g-aminobutyric acidA receptors (GABARs), the a subunit subtypes have been shown to be important for activation of the receptor by GABA and pento...

2012
M. N. Haque R. Chowdhury K. M. S. Islam M. A. Akbar

Propionic acid (PA) is a fungicide and bactericide, registered to control fungi and bacteria in stored grains, hay, grain storage areas, poultry litter, and drinking water for livestock and poultry. European Union (EU) certifies PA as the great of grain preserver and most efficient in controlling Salmonella and other pathogens. Recently it is used as feed additive in poultry and non-ruminant pr...

2013
Quentin M. Anstee Susanne Knapp Edward P. Maguire Alastair M. Hosie Philip Thomas Martin Mortensen Rohan Bhome Alonso Martinez Sophie E. Walker Claire I. Dixon Kush Ruparelia Sara Montagnese Yu-Ting Kuo Amy Herlihy Jimmy D Bell Iain Robinson Irene Guerrini Andrew McQuillin Elizabeth M.C. Fisher Mark A. Ungless Hugh M.D. Gurling Marsha Y. Morgan Steve D.M. Brown David N. Stephens Delia Belelli Jeremy J. Lambert Trevor G. Smart Howard C. Thomas

Alcohol dependence is a common, complex and debilitating disorder with genetic and environmental influences. Here we show that alcohol consumption increases following mutations to the γ-aminobutyric acidA receptor (GABAAR) β1 subunit gene (Gabrb1). Using N-ethyl-N-nitrosourea mutagenesis on an alcohol-averse background (F1 BALB/cAnN x C3H/HeH), we develop a mouse model exhibiting strong heritab...

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